环状RNA的出核机制及在肿瘤中作用的研究现状  

Research status on nuclear export mechanisms of circular RNA and its function in cancer

作　　者：谭芳[1] 胡娟 张鑫鑫 虞佳[1] 何柳柳 雷小勇[1] TAN Fang;HU Juan;ZhANG Xin-xin;YU Jia;HE Liu-liu;LEI Xiao-yong(Institute of Pharmacy and Pharmacology,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research,University of South China,Hengyang 421001,Hunan Province,China)

机构地区：[1]南华大学药物药理研究所、湖南省肿瘤微环境响应药物研究重点实验室、湖南省分子靶标新药研究协同创新中心,湖南衡阳421001

出　　处：《中国临床药理学杂志》2021年第7期918-921,933,共5页The Chinese Journal of Clinical Pharmacology

基　　金：湖南省自然科学青年基金资助项目(2018JJ3454;2019JJ50500);湖南省大学生创新训练基金资助项目(2315);衡阳市科技计划基金资助项目(2017KJ286)。

摘　　要：环状RNA(circRNA)作为一类非编码RNA(ncRNA),具备一些生物特性,包括特殊的圆环结构、较长的半衰期、相对保守性及较好的稳定性等。circRNA在各种疾病中的重要调控作用。并且circRNA可通过竞争性内源RNA(ceRNA)机制,转录调控外泌体携带等调控肿瘤进展。在此,本文阐述了circRNA的几种环化理论和相关出核机制,以及circRNA在肿瘤中顺利出核后,如何在胞质及胞外发挥其生物学功能。circRNA在多种肿瘤都可作为一个有前景的标志物。因此对circRNA出核机制及核外生物学功能的深入研究将为临床上的肿瘤治疗提供新线索。AS a class of non-coding RNAs(ncRNA),circular RNAs(circRNAs)can show some biological properties,including special circular structure,prolonged half-life,relatively conservative and better stability,etc.It has been verified that circRNA are essential to regulating various diseases.In addition,circRNA involved in tumorigenesis through competing endogenous RNAs(ceRNA)mechanism,transcriptional regulation and exosome-based delivery and so on.There,this paper elaborates several cyclization theories and correlated nuclear export mechanism.And,how do circRNA construe its biological function after are exported from the nucleus.Besides,circRNA are considered to be biomarkers for multiple tumors.In-depth study of circRNA export from nucleus and its biological function outside the nucleus will provide new clues for clinical management of tumors.

关 键 词：环状RNA 生物合成 成环理论 出核机制 肿瘤 

分 类 号：R97[医药卫生—药品]