Marine-derived fungi as a source of bioactive indole alkaloids with diversifed structures  

作　　者：Zhi-Hui Meng Tian-Tian Sun Guo-Zheng Zhao Yu-Fei Yue Qing-Hua Chang Hua-Jie Zhu Fei Cao 

机构地区：[1]College of Pharmaceutical Sciences,Institute of Life Science and Green Development,Hebei University,Baoding 071002,China

出　　处：《Marine Life Science & Technology》2021年第1期44-61,共18页海洋生命科学与技术（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.41606174,21877025);the Scientific Research Foundation of Hebei educational committee(No.BJ2020048);the China Postdoctoral Science Foundation(No.2019M661045);the Natural Science Interdisciplinary Research Program of Hebei University(No.DXK201913).

摘　　要：Marine-derived fungi are well known as rich sources of bioactive natural products.Growing evidences indicated that indole alkaloids,isolated from a variety of marine-derived fungi,have attracted considerable attention for their diverse,challenging structural complexity and promising bioactivities,and therefore,indole alkaloids have potential to be pharmaceutical lead compounds.Systemic compilation of the relevant literature.In this review,we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities,covering literatures published during 1982–2019.

关 键 词：Indole alkaloid Marine-derived fungus Chemical diversity Bioactivity 

分 类 号：Q93[生物学—微生物学]