植物生长调节剂的毒性研究进展  

Advances in Toxicity of Plant Growth Regulators

作　　者：岳可心 闫伊萌 张鸿旭 武家杰 刘忠英[1] 皮子凤[2,3] 马吉盛 刘志强 宋凤瑞[2] YUE Ke-xin;YAN Yi-meng;ZHANG Hong-xu;WU Jia-jie;LIU Zhong-ying;PI Zi-feng;MA Ji-sheng;LIU Zhi-qiang;SONG Feng-rui(Department of Pharmaceutical Analysis,Jilin University,Changchun 130021,China;National Center of Mass Spectrometry in Changchun,Key Laboratory of Traditional Chinese Medicine Chemistry and Mass Spectrometry Jilin Province,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;Changchun Sande Tiansheng Technology Co.,Changchun 130061,China)

机构地区：[1]吉林大学药学院药物分析教研室,长春130021 [2]中国科学院长春应用化学研究所长春质谱中心吉林省中药化学与质谱重点实验室,长春130022 [3]长春三德天晟科技有限公司,长春130061

出　　处：《农药》2021年第4期239-243,276,共6页Agrochemicals

基　　金：吉林省科技发展计划(20200404019YY,20190902020TC);吉林省预算内基本建设资金项目(2020C032-1)。

摘　　要：滥用植物生长调节剂(PGR)所导致的残留问题严重影响了人类的身体健康。常见的PGR毒性反应包括以下几方面:生殖毒性方面.可影响个体性激素水平、促进生精细胞的凋亡及抑制精子的活性;肝毒性方面.可干扰肝中ALT、AST和LDH等血清酶的活性,损伤肝细胞以及改变肝组织的正常形态;此外.PGR还具有免疫毒性、神经毒性、致畸、致癌、致突变、血液损伤、肾毒性、发育毒性和骨骼损伤等毒性作用。就国内外PGR毒性作用机理的研究情况进行了归纳总结,为深入研究PGR对机体的毒性机制提供依据,为合理有效防控PGR毒性损伤提供参考。The residual problems caused by the plant growth regulators(PGR)abuse have seriously affected human health.Common PGR toxic reactions include the following:reproductive toxicity,which can affect in dividual sex hormone levels,promote apoptosis of germ cells and inhibit sperm activity.Hepatotoxicity,which interferes with the activity of serum enzymes such as ALT,AST and LDH in the liver,damages hepatocytes and alters the normal morphology of liver tissue;in addition,PGR has toxic effects such as immunotoxicity,neurotoxicity,teratogenicity,carcinogenicity,mutagenicity,blood damage,nephrotoxicity,developmental toxicity,and skeletal damage.This paper summarizes the domestic and international PGR research,provides a basis for in-depth study of the mechanism of toxicity of PGR on body functions,and provides a reference for reasonable and effective prevention and control of PGR toxic injury.

关 键 词：植物生长调节剂 毒性 致毒机制 

分 类 号：TQ450.2[化学工程—农药化工]