天然来源的降木脂素类化合物及其生物活性研究进展  

Advances on natural sources norlignan compounds and their biological activities

作　　者：吴倩 王思成 盛文兵[1] 姚萌 袁汉文 王炜[1] 李斌[1] 彭彩云[1] WU Qian;WANG Si-cheng;SHENG Wen-bing;YAO Meng;YUAN Han-wen;WANG Wei;LI Bin;PENG Cai-yun(TCM and Ethnomedicine Innovation&Development International laboratory,School of pharmacy,Sino-Pakistan TCM&Ethnomedicine International Cooperation Base,Innovative Materia Medica Research Institute,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Chu Kochen Honors College,Zhejiang University,Hangzhou 310012,China)

机构地区：[1]湖南中医药大学药学院中药民族药物创新发展国际实验室,中巴中医药民族医药研究国际合作基地,创新药物研究所,湖南长沙410208 [2]浙江大学竺可桢学院,浙江杭州310012

出　　处：《中草药》2021年第5期1522-1535,共14页Chinese Traditional and Herbal Drugs

基　　金：湖南省自然科学基金(2020JJ4064);湖南省教育厅科研项目(20K095);湖南省科学技术厅重点研发计划项目(2018SK2119);湖南省药学一流学科开发基金项目(2020YX05);湖南中医药大学科研基金项目(2019XJJJ003)。

摘　　要：天然来源的降木脂素类化合物,结构类型复杂多样,分布广泛,根据2个苯丙素分子连接方式和连接位置的不同可将降木脂素分为降木脂素和降新木脂素。降木脂素类化合物具有抗肿瘤、抗过敏、抗炎、抗氧化和抗HIV及激素样作用等多种生物活性。主要对天然来源的降木脂素类化合物的结构类型及生物活性进行综述,为降木脂素类化合物的研究开发和应用提供依据。As a natural source compound, norlignan compounds have complex and diverse structure types with a wide of sources. Norlignan can be divided into norlignan and norneolignan by the difference of connection mode and position of two phenylpropanoid molecules. Norlignan have various biological activities such as anti-tumor, anti-allergy, anti-inflammatory, antioxidant, anti-HIV, and hormone-like effects. This review mainly describes the structure types and biological activities of natural sources of norlignan, providing a basis for the research development and application of norlignan.

关 键 词：降木脂素 降新木脂素 天然来源 结构类型 生物活性 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]