宽苞糙苏根降三萜化学成分研究  

Study on nortriterpenes from roots of Phlomis umbrosa var. latibracteata

作　　者：邓瑞雪[1] 黄玉阳 许艺凡[1] 刘普[1] DENG Rui-xue;HUANG Yu-yang;XU Yi-fan;LIU Pu(Luoyang Key Laboratory of Natural Products Functional Factor Research and Development,Chemical Engineering&Pharmaceutical College,Henan University of Science and Technology,Luoyang 471023,China)

机构地区：[1]洛阳市天然产物功能因子研究及产品开发重点实验室,河南科技大学化工与制药学院,河南洛阳471023

出　　处：《中草药》2021年第6期1555-1561,共7页Chinese Traditional and Herbal Drugs

基　　金：河南省高校科技创新人才支持计划(20HASTIT008);国家自然科学基金-河南联合基金资助项目(U1404831)。

摘　　要：目的研究宽苞糙苏Phlomis umbrosa var. latibracteata根降三萜类化学成分。方法用硅胶柱色谱、凝胶柱色谱、以及制备高效液相色谱等多种色谱分离手段进行分离纯化,用有机波谱手段鉴定分离得到的化合物结构。结果从宽苞糙苏根的95%乙醇提取物中分离得到8个降三萜类化合物,分别鉴定为糙苏醛A(1)、糙苏酮(2)、糙苏四醇A(3)、糙苏四醇B(4)、糙苏六醇A(5)、糙苏六醇B(6)、糙苏六醇C(7)、糙苏六醇D(8)。结论化合物1为新化合物,化合物3、4、6~8为首次从宽苞糙苏中分离得到的化合物,这些化合物表现出一定的肿瘤细胞抑制活性。Objective To study the nortriterpenes from the root of Phlomis umbrosa var. latibracteata. Methods The chemical constituents were isolated by repeated column chromatographies(Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. Results Eight nortriterpenes were isolated from the 95% ethanol aqueous extract of P. umbrosa var. latibracteata and the structures were identified as phlomisal A(1), phlomisone(2), phlomistetraol A(3), phlomistetraol B(4), phlomishexaol A(5), phlomishexaol B(6), phlomishexaol C(7), and phlomishexaol D(8). Conclusion Compound 1 is a new compound, and compounds 3, 4, 6—8 are isolated from this plant for the first time. All the nortriterpenes display varying degrees of antitumor activities against cancer cells in vitro.

关 键 词：宽苞糙苏 降三萜 抗肿瘤 糙苏醛A 糙苏四醇A 糙苏六醇B 

分 类 号：R284.1[医药卫生—中药学]