A homogenous microstructural Mg-based matrix model for orthopedic application with generating uniform and smooth corrosion product layer in Ringer’s solution:Study on biodegradable behavior of Mg-Zn alloys prepared by powder metallurgy as a case  

作　　者：Yang Yan Xin Chu Xier Luo Xuemei Xu Yu Zhang YiLong Dai Ding Li Liangjian Chen Tao Xiao Kun Yu 

机构地区：[1]School of Materials Science and Engineering,Central South University,Changsha 410083,China [2]Department of Materials Science and Engineering,Yantai Nanshan University,Yantai 265713,China [3]The Second Xiangya Hospital,Central South University,Changsha 410011,China [4]The Third Xiangya Hospital,Central South University,Changsha 410011,China

出　　处：《Journal of Magnesium and Alloys》2021年第1期225-240,共16页镁合金学报（英文）

基　　金：The authors acknowledge the Project(81472058)sup-ported by the National Natural Science Foundation of China;the financial support of the 2015 ShanDong province project of outstanding subject talent group.the project(LSD-KB1806);supported by the foundation of National Key labo-ratory of Shock Wave and Detonation Physics and the project(11802284);supported by the National Natural Science Foun-dation of China.The project(2017GK2120);supported by the Key Research and Development Program of Hunan Province and the Natural Science Foundation of Hunan Province of China(2018JJ2506).

摘　　要：For high corrosion resistance and extensively modified biodegradable Mg-based alloys and composites for bone implants,a new Mgbased matrix model prepared by powder metallurgy is discussed and developed.In this research,Mg-5 wt.%Zn alloys were selected as a case.And they were impacted by hot extrusion and aging treatments to construct microstructure with different characteristics.Their selfforming corrosion product layer in Ringer’s solution,biodegradable behavior and corrosion mechanism were minutely investigated by in vitro degradation,electrochemical corrosion and cytocompatibility.The results demonstrated the extruded Mg-5 wt.%Zn alloy aged for 96 h showed high corrosion resistance,good biocompatibility for L929 and excellent ability of maintaining sample integrity during the immersion.Significantly,the alloy showed fine-grain microstructure and uniform distributed hundred nano-sized second phases,which promoted the formation of the uniform and smooth corrosion product layer at the beginning of immersion.The corrosion product layer was more stable in chloride containing aqueous solution and could be directly formed and repaired quickly,which effectively protected the matrix from further corrosion.In addition,an ideal model of Mg-based matrix for bone tissue engineering was tried to presume and propose by discussing the causal relationship between microstructure and bio-corrosion process.

关 键 词：Magnesium alloys Powder metallurgy Second phase Corrosion product layer Biodegradable behavior CYTOCOMPATIBILITY 

分 类 号：TG172[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]