重组人脑利钠肽联合小剂量多巴胺对急性心肌梗死合并泵功能不全患者急性期疗效及近期预后影响  

Effect of Recombinant Human Brain Natriuretic Peptide Combined with Low Dose Dopamine on Acute Phase Efficacy and Short-term Prognosis in Patients with Acute Myocardial Infarction and Pump Insufficiency

作　　者：王楚林 徐名伟 吴强 徐衡 张华弟 刘琳琪 WANG Chulin;XU Mingwei;WU Qiang;XU Heng;ZHANG Huadi;LIU Linqi(The People’s Hospital of Jieyang City(Jieyang Hospital Affiliated to Sun Yatsen University),Jieyang 522000,China;不详)

机构地区：[1]广东省揭阳市人民医院(中山大学附属揭阳医院),广东揭阳522000

出　　处：《中国医学创新》2021年第4期14-18,共5页Medical Innovation of China

摘　　要：目的:探究重组人脑利钠肽联合小剂量多巴胺治疗对急性心肌梗死合并泵功能不全患者急性期疗效及近期预后影响。方法:选取2017年1月-2019年12月本院收治的70例急性心肌梗死合并泵功能不全患者,按照随机数字表法将其分为对照组和试验组,各35例。对照组采用硝普钠等常规治疗,试验组在使用硝普钠基础上联合重组人脑利钠肽和小剂量多巴胺治疗,比较两组患者急性期泵功能分级改善情况、左室射血分数(LVEF)、N末端B型钠尿肽原(NT-proBNP)、心率(HR)、平均动脉压(MAP)等指标以及治疗后3个月6 min步行试验,治疗3月内主要不良心血管事件、再次住院率指标。结果:治疗后,试验组泵功能级别、NT-proBNP指标、心率均低于对照组,LVEF、MAP水平均高于对照组,差异均有统计学意义(P<0.05)。试验组3月后6 min步行试验距离较对照组明显改善,差异有统计学意义(P<0.05)。两组主要不良心血管事件发生率比较,差异有统计学意义(P<0.05)。试验组3个月内再次住院1例(2.86%),对照组3个月内再次住院2例(5.71%),两组比较差异无统计学意义(P>0.05)。结论:急性心肌梗死合并泵功能不全患者经重组人脑利钠肽联合小剂量多巴胺治疗,能有效改善急性期泵功能,减少主要不良心血管事件,改善近期预后,值得全面推广。Objective:To investigate the effect of Recombinant Human Natriuretic Peptide combined with low dose Dopamine on the acute phase efficacy and short-term prognosis of patients with acute myocardial infarction complicated with pump insufficiency.Method:A total of 70 patients with acute myocardial infarction complicated with pump insufficiency admitted to our hospital from January 2017 to December 2019 were selected,they were divided into control group and experimental group according to random number table method,35 cases in each group.The control group using conventional treatment of Sodium Nitroprusside Dihydrate,patients in the experimental group based on the control group combination of Recombinant Human Brain Natriuretic Peptide and small dose Dopamine treatment,compared two groups of patients with acute stage pump function classification to improve the situation,the left ventricular ejection fraction(LVEF),N end of B-type natriuretic peptide(NT-proBNP),heart rate(HR),mean arterial pressure(MAP),and 3 months after treatment 6 min walking test,3 months major adverse cardiac events,readmission rate index.Result:After treatment,pump function level,NT-proBNP index and heart rate in experimental group were lower than those in control group,while LVEF and MAP were higher than those in control group,the differences were statistical significance(P<0.05).The walking distance of the experimental group at 6 min after 3 months after treatment was significantly improved compared with the control group,the difference was statistically significant(P<0.05).There was statistical significance in the incidence of major adverse cardiovascular events between the two groups within 3 months of treatment(P<0.05).In the experimental group,1 case(2.86%)was hospitalized again within 3 months,in the control group,2 cases(5.71%)were hospitalized again within 3 months,there was no difference statistical significance between the two groups(P>0.05).Conclusion:Patients with acute myocardial infarction with pump insufficiency were treated with

关 键 词：重组人脑利钠肽 小剂量多巴胺 急性心肌梗死 泵功能不全 

分 类 号：R542.22[医药卫生—心血管疾病]