抗精神病药物对男性精神分裂症患者性功能的影响  

The Effect of Antipsychotic Drugs on the Sexual Function of Male Patients with Schizophrenia

作　　者：徐杨[1] 王京 王彬[1] 高庆强[1] 余文[1] 徐志鹏[1] XU Yang;WANG Jing;WANG Bin;GAO Qing-qiang;YU Wen;XU Zhi-peng(Department of Andrology,Nanjing Gulou Hospital,Nanjing University School of Medicine,Nanjing,Jiangsu Province,210000 China)

机构地区：[1]南京大学医学院附属南京鼓楼医院男科,江苏南京210000

出　　处：《中外医疗》2021年第7期106-109,共4页China & Foreign Medical Treatment

摘　　要：目的分析男性精神分裂症患者使用抗精神类药物后对其性功能造成的影响。方法方便选取该院在2017年4月—2019年4月收治的80例男性精神分裂症患者进行研究,按照患者入院先后顺序将其分组。其中对比组患者(n=40)行单一认知疗法干预,研究组患者(n=40)在认知疗法干预基础上服用抗精神类药物(利培酮),对比两组患者最终治疗效果。结果研究组患者治疗后总有效率(95.0%)高于对比组患者治疗有效率(37.5%),差异有统计学意义(χ^(2)=29.574,P<0.05);研究组患者治疗后性功能评分高于对比组患者治疗后性功能评分,差异有统计学意义(P<0.05);研究组患者治疗后性激素水平明显差于对比组,差异有统计学意义(P<0.05)。结论男性精神分裂症患者使用抗精神类药物后对其性功能会造成一定影响,患者服药后性欲以及性唤起下降,患者机体中多巴胺等显著提升,故临床中应用抗精神类药物治疗精神分裂症过程中需严格按照患者病情酌情给药。Objective To analyze the effects of antipsychotic drugs on the sexual function of male patients with schizophrenia.Methods convenient select s study was conducted on 80 male patients with schizophrenia admitted to the hospital from April 2017 to April 2019,and the patients were divided into two groups according to the order in which they were admitted to the hospital.Patients in the comparison group(n=40)underwent single cognitive therapy intervention,and patients in the study group(n=40)took antipsychotic drugs(risperidone)on the basis of cognitive therapy intervention to compare the final treatment effects of the two groups.Results After treatment,the total effective rate of patients in the study group(95.0%)was higher than that of patients in the control group,and the effective rate(37.5%),and the difference was statistically significant(χ^(2)=29.574,P<0.05);the sexual function scores of the patients in the study group after treatment were higher than those in the control group.The post-sexual function score,and the difference was statistically significant(P<0.05);the level of sex hormones in the study group was significantly worse than that of the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion The use of antipsychotic drugs in male patients with schizophrenia will have a certain impact on their sexual function.After taking the drug,the libido and sexual arousal of the patients decrease,and the dopamine in the patient's body is significantly increased.Therefore,antipsychotic drugs are used in the clinical treatment of schizophrenia.During the treatment process,the medication should be administered strictly according to the patient's condition.

关 键 词：抗精神病药物 男性 精神分裂症 性功能 

分 类 号：R4[医药卫生—临床医学]