左氧氟沙星与吡嗪酰胺治疗复治肺结核合并糖尿病的临床效果比较  

Comparison of the Clinical Effects of Levofloxacin and Pyrazinamide in the Treatment of Retreatment of Pulmonary Tuberculosis Complicated with Diabetes

作　　者：刘贵学 LIU Gui-xue(Second Department of Tuberculosis,Heze Infectious Disease Hospital,Heze,Shandong Province,274000 China)

机构地区：[1]菏泽市传染病医院结核二科,山东菏泽274000

出　　处：《中外医疗》2021年第7期119-121,共3页China & Foreign Medical Treatment

摘　　要：目的对比左氧氟沙星与吡嗪酰胺治疗复治肺结核合并糖尿病的临床效果。方法方便选择2018年6月—2019年5月该院收治的82例复治肺结核合并糖尿病患者作为研究对象,以随机数字表法将其随机分为两组,其中对照组与研究组各41例。两组均采取常规降糖方案治疗,对照组应用利福平、异烟肼、乙胺丁醇、吡嗪酰胺治疗,研究组应用利福平、异烟肼、乙胺丁醇、左氧氟沙星治疗。对比两组患者治疗前后的血糖水平(空腹血糖与餐后2 h血糖),治疗后肺结核病灶吸收率、空洞缩小率与痰菌转阴率,治疗期间药物不良反应情况(肝功能损伤、肾功能损伤、胃肠道反应、皮疹)。结果治疗后研究组空腹血糖(6.5±0.4)mmol/L、餐后2 h血糖(10.6±2.3)mmol/L与对照组(6.4±0.5)mmol/L、(10.8±2.0)mmol/L对比差异无统计学意义(t=1.000、0.420,P>0.05)。研究组治疗后肺结核病灶吸收、空洞缩小与痰菌转阴的发生率92.68%、95.12%、95.12%高于对照组73.17%、78.05%、78.05%,差异有统计学意义(χ^(2)=5.513、5.145、5.145,P<0.05)。研究组药物不良反应发生率9.76%低于对照组26.83%,差异有统计学意义(χ^(2)=3.998,P<0.05)。结论相较于吡嗪酰胺,左氧氟沙星治疗复治肺结核合并糖尿病疗效与安全性更为理想,适于临床应用。Objective To compare the clinical effects of levofloxacin and pyrazinamide in the treatment of retreatment of pulmonary tuberculosis complicated with diabetes.Methods Convenient to select 82 patients with retreated pulmonary tuberculosis and diabetes mellitus admitted to the hospital from June 2018 to May 2019 were selected as the research objects,and they were randomly divided into two groups by random number table method,of which 41 cases were in the control group and 41 cases in the study group.Both groups were treated with conventional hypoglycemic regimens.The control group was treated with rifampicin,isoniazid,ethambutol,and pyrazinamide,and the study group was treated with rifampicin,isoniazid,ethambutol,and levofloxacin.The blood glucose levels before and after treatment(fasting blood glucose and 2 h postprandial blood glucose)were compared between the two groups of patients,the absorption rate of pulmonary tuberculosis lesions,the rate of cavity reduction,and the rate of sputum bacteria conversion after treatment,and the adverse drug reactions during the treatment(liver damage,renal damage,gastrointestinal reactions,skin rashes).Results After treatment,fasting blood glucose(6.5±0.4)mmol/L and 2 h postprandial blood glucose(10.6±2.3)mmol/L in the study group were compared with those in the control group(6.4±0.5)mmol/L,(10.8±2.0)mmol/L.There was no statistical significance(t=1.000,0.420,P>0.05).After treatment,the incidence of tuberculosis lesion absorption,cavity reduction,and sputum negative in the study group were 92.68%,95.12%,and 95.12%higher than those in the control group(73.17%,78.05%,and 78.05%),the difference was statistically significant(χ^(2)=5.513,5.145,5.145,P<0.05).The incidence of adverse drug reactions in the study group was 9.76%lower than that in the control group,26.83%,the difference was statistically significant(χ^(2)=3.998,P<0.05).Conclusion Compared with pyrazinamide,levofloxacin is more effective and safer in the treatment of retreatment of pulmonary tuberculosis complicated

关 键 词：左氧氟沙星 吡嗪酰胺 复治肺结核 糖尿病 

分 类 号：R521[医药卫生—内科学]