五指毛桃对小鼠酒精性肝损伤的保护作用  

Protective effect of Fici Hirtae Radix on mice with alcoholic liver injury

作　　者：张茹[1] 杜娟 ZHANG Ru;DU Juan(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076

出　　处：《哈尔滨商业大学学报（自然科学版）》2021年第2期139-144,共6页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：哈尔滨商业大学青年创新人才培养计划(17XN034).

摘　　要：探讨五指毛桃对小鼠酒精性肝损伤的保护作用.将小鼠随机分为空白对照组、模型对照组、葛花组、五指毛桃低、中、高剂量组,葛花组按0.53 g/(kg·d)剂量灌胃葛花提取物;五指毛桃低、中、高剂量组按0.2 g/(kg·d)、0.4 g/(kg·d)、0.6 g/(kg·d)剂量灌胃五指毛桃提取液;空白对照组和模型对照组灌胃等量0.9%生理盐水.30 min后,除空白对照组外剂量组和模型对照组分别按剂量10 mL/kg灌胃牛栏山二锅头(56%乙醇),连续灌胃10天,考察体重、自主活动次数、肝脏指数、GSH含量、SOD活性、TNF-α、NF-κB、IL-1β和IL-6的水平.各组小鼠体重无显著性差异.与空白对照组相比,模型对照组自主活动次数、肝脏指数、IL-6、IL-1β、TNF-α和NF-κB水平均有所升高,GSH含量、SOD活性均有所下降;与模型对照组相比,低、中、高剂量的五指毛桃组均在不同程度上降低肝脏指数、IL-6、IL-1β、TNF-α、NF-κB水平,升高GSH含量和SOD活性.五指毛桃对小鼠酒精性肝损伤具有一定的保护作用.To explore the protective effect of Fici Hirtae Radix on mice with alcoholic liver injury.The mice were randomly divided into blank control group,model control group,fios puerariae group(0.53 g/kg),Fici Hirtae Radix lowdose group(0.2 g/kg),Fici Hirtae Radix medium dose group(0.4 g/kg)and Fici Hirtae Radix high dose group(0.6 g/kg).The blank control group and the model group were given 0.9%normal saline,and the other groups were given the prescribed dose.After 30 minutes,except the blank control group,the dosage group and the model control group were given 10 mL/kg doses of Niulanshan Erguotou(56%ethanol)to mice for 10 days,investigating the body weight of mice,number of autonomous activities,liver index,GSH content,SOD activity,TNF-α、NF-κB、IL-1βand IL-6levels.There was no significant difference in body weight of mice.Compared with the blank control group,number of autonomic activities,the levels of liver index,IL-6、IL-1β、TNF-αand NF-κB were increasedin model group,and GSH content and SOD activity were decreased;compared to the model group,the levels of liver index,IL-6、IL-1β、TNF-α、NF-κB were decreased in Fici Hirtae Radix lowdose group,Fici Hirtae Radix mediumdose group and Fici Hirtae Radix high dose group,GSH content and SOD activity were increased.Fici Hirtae Radix has protective effect on mice with alcoholic liver injury.

关 键 词：五指毛桃 酒精性肝损伤 护肝作用 小鼠 抗氧化 抗炎 

分 类 号：R961.1[医药卫生—药理学]