树突状细胞标记CD123、FXⅢA、CD1a在麻风病皮损中的表达及其意义  

Expression and significance of dendritic cell markers CD123,FXⅢA and CD1a in leprosy lesions

作　　者：周文军 秦雁 ZHOU Wenjun;QIN Yan(Guangxi Zhuang Autonomous Region Institute of Dermatology,Nanning 530003,China)

机构地区：[1]广西壮族自治区皮肤病防治研究所,广西南宁530003

出　　处：《皮肤性病诊疗学杂志》2021年第1期19-23,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广西皮肤性病科临床重点专科建设项目(桂卫医发[2019]44号)。

摘　　要：目的:探讨树突状细胞在麻风病发病中的作用。方法:采用免疫组织化学染色法,观察3种树突状细胞标记(CD123、FXⅢA、CD1a)在麻风病皮损中的表达情况,并分析其意义。结果:CD123、FXⅢA、CD1a三种抗体标记在少菌型麻风结核样肉芽肿中均有较明显的表达,而在多菌型麻风中未见表达或仅见个别阳性细胞。结论:CD123、FXⅢA、CD1a阳性的树突状细胞参与了麻风病细胞免疫反应,并促进疾病往少菌型方向发展。Objective:To explore the role of dendritic cells in the pathogenesis of leprosy.Method:The expression of three dendritic cell markers(CD123,FXⅢA,CD1a)in leprosy lesions was assessed by immunohistochemical staining,and their significance was analyzed.Results:Expression of CD123,FXⅢA and CD1a was observed in tuberculoid granulomas of paucibacillary leprosy lesion,while lesion of multibacillary leprosy displayed no or minimal expression.Conclusions:CD123,FXⅢA and CD1a positive dendritic cells participate in the cellular immune response in leprosy,and promote the development of the disease toward paucibacillary type.

关 键 词：麻风 树突状细胞 免疫组化 CD123 FXⅢA CD1A 

分 类 号：R755[医药卫生—皮肤病学与性病学]