精神专科医院住院患者口服片剂分劈使用情况统计与分析  

Analysis of Splitting of Oral Tablets by Inpatients in a Psychiatric Hospital

作　　者：戴彪 梁俊[1,2,3] 夏清荣 徐亚运[1,2,3] 曹银 吴晓平[1,2,3] DAI Biao;LIANG Jun;XIA Qingrong;XU Yayun;CAO Yin;WU Xiaoping(Affiliated Psychological Hospital of Anhui Medical University,Hefei Anhui 230022,China;Department of Mental Pharmacology,Anhui Mental Health Center,Hefei Anhui 230022,China;Department of Pharmacy,Hefei Fourth People's Hospital,Hefei Anhui 230022,China)

机构地区：[1]安徽医科大学附属心理医院,安徽合肥230022 [2]安徽省精神卫生中心精神药理研究室,安徽合肥230022 [3]合肥市第四人民医院药剂科,安徽合肥230022

出　　处：《中国药物警戒》2021年第4期373-376,380,共5页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金(81671316)。

摘　　要：目的对某精神专科医院住院患者口服片剂分劈使用情况进行统计与分析,以期为精神专科医院住院患者的用药安全性和有效性提供参考。方法收集2019年9月至2020年2月安徽医科大学附属心理医院住院患者口服片剂的医嘱,分别从分劈医嘱数前20位的药品名称、分类类别、科室、性别以及年龄等方面进行统计与分析。结果总分劈医嘱数占医嘱总数的比例为10.58%;分劈剂量为1/2的医嘱数占比最多(94.77%)。住院患者口服分劈医嘱数居前的药品主要有利培酮、氯硝西泮、喹硫平、氯氮平和奥氮平等,科室主要有普通精神科、老年心理科和儿童青少年科等,种类主要有抗精神病药、镇静催眠药和抗抑郁药等。女性患者分劈医嘱比例高于男性,儿童青少年和老年患者分劈医嘱比例高于成人。结论由于专科用药及剂量使用的需要,口服片剂分劈情况在精神专科医院住院患者药品使用中广泛存在,药师应对药品分劈的质量进行把关,以促进临床合理用药,保证患者用药的安全性和有效性。Objective To analyze statistically the splitting of oral tablets for inpatients in a psychiatric hospital in order to provide reference for the safety and effectiveness of medication.Methods The medical orders for oral tablets given to inpatients in our hospital between September 2019 and February 2020 were collected.The top 20 medicines were analyzed statistically in terms of names,types,departments involved,and gender and age of patients.Results The percentage of medical orders for splitting of tablets among the total orders for tablets was 10.58%.The number of medical orders with the split dose of 1/2 was the largest,accounting for 94.77%.The top drugs involving splitting of tablets included risperidone,clonazepam,quetiapine,clozapine and diazepam.Departments with the largest number of medical orders for splitting tablets for inpatients were the Department of General Psychiatry,Department of Geriatric Psychology and Department of Diseases of Children and Adolescents.Antipsychotics,sedative hypnotics and antidepressants were dominating.Medical orders for splitting of tablets for female patients outnumbered those for male ones.Conclusion As required by special medicines and dosage,the splitting of oral tablets is widely used among inpatients in psychiatric hospitals.Pharmacists should check the quality of the splitting of oral tablets in order to promote the clinical rational use of drugs and ensure the safety and effectiveness of medication.

关 键 词：住院患者 口服给药 片剂分劈 精神专科医院 

分 类 号：R994.11[医药卫生—毒理学]