带状疱疹神经痛患者应用普瑞巴林致肌阵挛的药学监护  

Myoclonus Caused by Pregabalin in Patients with Herpes Zoster Neuralgia and Literature Analysis

作　　者：蔡江霞 杜宪 孙培环 张笑颖 刘涛 叶银梅[1] CAI Jiangxia;DU Xian;SUN Peihuan;ZHANG Xiaoying;LIU Tao;YE Yinmei(Department of Pharmacy,the People's Hospital of Xinjiang Bayinguoleng Mongolian Autonomous Prefecture,Korla Xinjiang 841000,China)

机构地区：[1]新疆巴音郭楞蒙古自治州人民医院药学部,新疆库尔勒841000

出　　处：《中国药物警戒》2021年第4期381-383,387,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(71904155)。

摘　　要：目的探讨普瑞巴林与二氢吡啶类钙通道拮抗剂(calcium channel blockers,CCB)类降压药联用的安全性及药学监护。方法基于1例带状疱疹神经痛患者应用普瑞巴林致肌阵挛的病例,查阅国内外文献并结合其疾病特点及用药,对患者发生肌阵挛的原因进行分析评价,总结出药品不良反应(ADR)防范及药学监护要点。结果普瑞巴林与CCB类降压药物需谨慎联用,若联用需做好相应的监护。结论临床药师参与临床治疗药物监护有利于保障患者的药物选择、用药禁忌、ADR防范等方面用药安全。Objective To investigate the safety and pharmaceutical care of pregabalin used in combination with CCB antihypertensive drugs.Methods Based on one case of pregabalin-induced myoclonus in a patient with herpes zoster neuralgia,the clinical pharmacist reviewed domestic and foreign literature,studied the characteristics of the disease and medication,analyzed the causes of myoclonus in the patient,and summarized the bottom line of prevention of adverse reactions and pharmaceutical care for clinical reference.Results The clinical pharmacist proposed that the combination of pregabalin and CCB antihypertensive drugs be used with caution.Conclusion It is essential that clinical pharmacists participate in the monitoring of clinically-used drugs,which can contribute to drug safety of patients and prevention of adverse reactions.

关 键 词：带状疱疹神经痛 普瑞巴林 钙通道拮抗剂 药品不良反应 

分 类 号：R994.1[医药卫生—毒理学]