反复种植失败人群年龄、BMI与非整倍体的关系分析  

Association of age and body mass index with embryonic aneuploidy on patients with repeated implantation failures

作　　者：罗燕群[1] 李辉斌[1] 黄翠玉[1] 黄莉[1] 朱秀兰[1] 张曦倩[1] 刘风华[1] Luo Yanqun;Li Huibin;Huang Cuiyu;Huang Li;Zhu Xiulan;Zhang Xiqian;Liu Fenghua(Center for Reproductive Medicine,Guangdong Women&Children Hospital,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院生殖医学中心,广东广州511442

出　　处：《中国产前诊断杂志（电子版）》2021年第1期37-42,共6页Chinese Journal of Prenatal Diagnosis(Electronic Version)

基　　金：广州市科技计划(201704020217);广东省医学科学技术研究基金(B2019019)。

摘　　要：目的探讨年龄、身体质量指数(body mass index,BMI)对反复种植失败人群的非整倍体的影响。方法共纳入2017年5月至2020年6月因反复种植失败行植入前非整倍性基因测试(preimplantation genetic testing for aneuploidy,PGT-A)治疗的79个周期,按取卵年龄分<35岁组和35~39岁组,再进一步根据不同年龄组的BMI分体重过低组(<18.5kg/m^(2))、正常组(18.5~23.9kg/m^(2))和超重组(24.0~27.9kg/m^(2))。比较胚胎整倍体率等结果。结果<35岁组患者囊胚整倍体数和整倍体率明显高于35~39岁组(P<0.05),不同BMI组间(体重过低、正常和超重)患者的年龄、基础卵泡刺激素水平、抗苗勒管激素、囊胚整倍体数和整倍体率间差异无明显统计学意义(P>0.05)。进一步比较不同年龄分层分析不同BMI组间囊胚整倍体数和整倍体率间差异仍无明显统计学意义,但35~39岁年龄段体重正常组的囊胚形成率最高,差异有明显统计学意义。结论当反复种植失败患者年龄增加至35~39岁时,整倍体率明显降低以及体重指数的异常可能影响囊胚形成率。超重以及体重过低可能不影响反复种植失败患者的非整倍体率。Objective To explore the effects of age and BMI on the aneuploidy of patients with repeated implantation failures.Methods A total of 79 cycles of PGT-Adue to repeated implantation failures were between May 2017 and June 2020 included.Women were divided into two age groups(<35 and 35~39 years).Patients were grouped by BMI class:underweight(<18.5 kg/m^(2)),normal weight(18.5~23.9 kg/m^(2)),overweight(24.0~27.9 kg/m^(2)).The number of euploid embryos or the percentage of euploid embryos was compared.Results The number of euploid embryos or the percentage of euploid embryos in women aged<35 years was significantly higher than that in women aged 35~39 years(P<0.05).There were no significant differences in the age or basic FSH level or anti-Müllerian hormone or the number of euploid embryos or the percentage of euploid embryos by BMI category(P>0.05).Age was inversely related to euploidy,by adjusting ages,there were also no significant differences in the number of euploid embryos or the percentage of euploid embryos,but the patients aged 35~39 years in the normal BMI group had the highest formed blastulation rate;and there was statistically significant difference between BMI groups when comparing the formed blastulation rate in underweight patients and overweight patients.Conclusion The percentage of euploid embryos decrease and abnormal body mass index may cause low formed blastulation rate when age of RIF patients older than 34 years.Overweight and underweight does not affect the euploid embryos percentage of patients with repeated implant failure.

关 键 词：反复种植失败 非整倍体 年龄 身体质量指数 

分 类 号：R711.6[医药卫生—妇产科学]