基于中医传承辅助平台的王阶教授治疗频发室性早搏用药经验传承  

Research on inheritance of Professor WANG Jie’s Experience in Treatment of Frequent Ventricular Premature Complexes Based on Inheritance Support System of Traditional Chinese Medicine

作　　者：李洪峥 赵鑫[2] 王阶[2] 但文超[1,2] 张辉 连文静[1,2] 何庆勇[2] LI Hong-zheng;ZHAO Xin;WANG Jie;DAN Wen-chao;ZHANG Hui;LIAN Wen-jing;HE Qing-yong(Beijing University of Chinese Medicine,Beijing 100029,China;Guang’anmen Hospital,China Academy of Chinese Medicinal Sciences,Beijing 100053,China;Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院广安门医院,北京100053 [3]河南中医药大学,郑州450000

出　　处：《中国实验方剂学杂志》2021年第7期161-168,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医传承与创新“百千万”人才工程(岐黄工程)——国家中医药领军人才支撑计划项目。

摘　　要：目的:借助中医传承辅助平台(V2.5)软件,研究王阶教授治疗频发性室性早搏的用药经验与组方规律,传承王阶教授临床诊疗频发室性早搏的经验。方法:收集并整理王阶教授2016-2020年治疗频发室性早搏的医案处方,采用改进的互信息法、关联规则、复杂系统熵聚类、无监督的熵层次聚类,对处方中药物的性味、归经、应用频次、药对组合等进行统计、关联规则分析与新方发现。结果:共收集王阶教授治疗频发室性早搏处方122则,中药110味,多为辛、甘药物,归经则以脾经为主,兼有心、肾、肝、肺、胃经。使用单药频次最高的桂枝、白芍、生牡蛎、生龙骨、炙甘草、大枣,高频对药为桂枝-白芍116次(占95.08%);常用角药为桂枝-生龙骨-生牡蛎108次(占88.52%),桂枝-白芍-生龙骨106次(占86.89%),桂枝-白芍-生牡蛎106次(占86.89%)。常用药对为木香-砂仁等。核心处方药物为桂枝-白芍-炙甘草-生姜-大枣-生龙骨-生牡蛎-牛膝-党参-黄芪-肉苁蓉-茯苓-酸枣仁。结论:王阶教授治疗频发室性早搏的用方以桂枝加龙骨牡蛎汤为主,药物以桂枝、白芍、生牡蛎、生龙骨、炙甘草、大枣等为主,临床诊疗时随病、证、症进行用药加减。Objective:With the aid of the Inheritance Support System of Traditional Chinese Medicine V2.5(TCMISS V2.5),to study the experience and prescription rules of professor WANG Jie in the treatment of frequent ventricular premature complexes,and inherit his clinical experience in diagnosis and treatment.Method: Professor WANG Jie’s medical records and prescriptions for frequent ventricular premature complexes from 2016 to 2020 were collected and sorted out. Improved mutual information method,association rules,complex system entropy clustering,and unsupervised entropy hierarchical clustering were used to analyze the nature and flavor,channel tropism,concerted application rules,pair and combination of herbs for statistics,association rules analysis and discovery of new prescriptions. Result: A total of 122 prescriptions of professor WANG Jie on the treatment of frequent ventricular premature complexes were collected. 110 herbs,mostly with pungent and sweet flavors,were mainly on spleen channel and also on heart,kidney,liver,lung,and stomach channels. Cinnamomi Ramulus,Paeoniae Alba Radix,Os Draconis,Ostreae Concha,Glycyrrhizae Radix,and Jujubae Fructus had the highest frequency in use. The high-frequency herbal pair was Cinnamomi RamulusPaeoniae Alba Radix(116 times,accounting for 95.08%),the commonly used corner drugs were Cinnamomi Ramulus-Os Draconis-Ostreae Concha(108 times,88.52%),Cinnamomi Ramulus-Paeoniae Alba Radix-Ostreae Concha(106 times,86.89%),Cinnamomi Ramulus-Paeoniae Alba Radix-Os Draconis(106 times,86.89%).Commonly used herbal pair was Aucklandiae Radix-Amomi Villosi Fructus. The core prescription herbs included Cinnamomi Ramulus-Paeoniae Alba Radix-Os Draconis-Ostreae Concha-Glycyrrhizae Radix-Jujubae FructusZingiberis Recens Rhizoma-Achyranthis Bidentatae Radix-Codonopsis Radix-Astragali Seu Hedysari RadixCistanches Herba-Poria-Ziziphi Spinosae Semen. Conclusion: Professor WANG Jie’s prescription for the treatment of frequent ventricular premature complexes is Guizhi Jia Longgu Mulitang,and the mai

关 键 词：组方分析 用药规律 室性早搏 中医传承辅助系统 核心药物 

分 类 号：R714.252[医药卫生—妇产科学] R289[医药卫生—临床医学]