正交试验法优选利湿通淋颗粒的水提工艺  

Water Extracting Technique Optimization of Lishitonglin Granules by Orthogonal Test Method

作　　者：袁敏[1] 梁瑞雪[1] 刘青[1] YUAN Min;LIANG Rui-xue;LIU Qing(Shandong Academy of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东省中医药研究院,济南250014

出　　处：《当代化工》2021年第2期274-277,共4页Contemporary Chemical Industry

基　　金：山东省科技厅重点研发计划资助项目(项目编号:2018GSF119023、2018GSF119001);山东省中医药管理局中医药科技发展计划(项目编号:2017-134、2011-173)。

摘　　要：优选利湿通淋颗粒的水提工艺,为利湿通淋颗粒的应用开发提供参考数据。以益母草碱转移率和干膏得率的综合评分为评价指标,采用L9(3^(3))正交试验设计,优选利湿通淋颗粒的最佳水提工艺。优选的最佳水提工艺为:醇提后的药渣与蒲公英、益母草等五味饮片混合,加水量分别为饮片总重的14倍、12倍、12倍量,水煎煮3次,每次1.5h。优选的利湿通淋颗粒水提工艺合理可行,重复性好,为利湿通淋颗粒的研发提供科学依据。To optimize water extracting technique of Lishitonglin Granules and lay the foundationfor the application development of Lishitonglin Granules. Taking the composite score of transfer rate of Leonurine and the dry paste yield as the evaluation index, L9(3^(3)) orthogonal experimental design was used to select the optimum water-extracting process conditions of Lishitonglin Granules. The optimum of Lishitonglin Granules was as follows:the residue of ethanol extraction was mixed with 5 kinds of medicinal materials,such as Taraxaci and Leonuri herba and so on, and they were boiled 3 times with water for 1.5 h each time, the amount of water was 14 times,12 times, and 12 times. Optimized preparation process of Lishitonglin granules was reasonable and feasible, providing reference data for research and development of Lishitonglin Granules.

关 键 词：利湿通淋颗粒 水提工艺 正交试验设计 

分 类 号：R283.6[医药卫生—中药学]