低分子肝素治疗脓毒症的效果探讨  

Discussion on the effect of low-molecular-weight heparin on sepsis

作　　者：颜廷卿 曹坤 魏秀春 YAN Ting-qing;CAO Kun;WEI Xiuchun(Department of Intensive Medicine,Liaocheng Traditional Chinese Medicine Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市中医医院重症医学科,252000 [2]聊城市中医医院妇产科,252000

出　　处：《中国现代药物应用》2021年第7期97-99,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析低分子肝素治疗脓毒症的临床效果。方法80例脓毒症患者,采取随机数字表法分为对照组与观察组,每组40例。对照组给予常规治疗,观察组在对照组基础上加用低分子肝素治疗。对比两组治疗前后凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、C反应蛋白(CRP)]、急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、随访28 d生存率及不良反应发生率。结果治疗后第7天,观察组PT、APTT短于对照组、PLT高于对照组、CRP水平低于对照组,差异有统计学意义(P<0.05)。治疗后第7天,观察组APACHEⅡ评分(12.60±4.36)分低于对照组的(18.75±9.11)分,差异有统计学意义(P<0.05)。观察组随访28 d生存率95.00%高于对照组的77.50%,差异有统计学意义(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论低分子肝素治疗脓毒症可有效改善凝血功能指标,患者生存率较高,同时未增加不良反应发生率,保证了用药的安全性。Objective To analyze the clinical effect of low-molecular-weight heparin on sepsis.Methods A total of 80 sepsis patients were divided into control group and observation group according to random numerical table,with 40 cases in each group.The control group was treated with conventional therapy,and the observation group was treated with low-molecular-weight heparin based on the control group.The coagulation function indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),platelet(PLT)count,C-reactive protein(CRP)],acute physiology and chronic health evaluation(APACHEⅡ)score before and after treatment,and 28-d follow-up survival rate and incidence of adverse reactions were compared between the two groups.Results After 7 days of treatment,the PT and APTT of the observation group were shorter than those of the control group,PLT was higher than that of the control group,and CRP was lower than that of the control group.All the difference was statistically significant(P<0.05).After 7 days of treatment,the APACHEⅡscore(12.60±4.36)points of the observation group was lower than(18.75±9.11)points of the control group,and the difference was statistically significant(P<0.05).The 28-d follow-up survival rate 95.00%of the observation group was higher than 77.50%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-molecular-weight heparin for the treatment of sepsis can effectively promote the improvement of coagulation function indicators,the survival rate of patients is relatively high,while the incidence of adverse reactions does not increase,thus ensuring the safety of medication.

关 键 词：低分子肝素 脓毒症 凝血功能指标 预后 

分 类 号：R459.7[医药卫生—急诊医学]