超快激光调控晶体形核与生长过程研究进展  

Progress in Ultrafast Laser-Induced Nucleation and Crystal Growth

作　　者：俞嘉晨 闫剑锋[1] 李欣[2] 曲良体 Yu Jiachen;Yan Jianfeng;Li Xin;Qu Liangti(Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China;School of Mechanical Engineering,Beijing Institute of Technology,Beijing 100081,China;Department of Chemistry,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学机械工程系,北京100084 [2]北京理工大学机械车辆学院,北京100081 [3]清华大学化学系,北京100084

出　　处：《中国激光》2021年第2期316-330,共15页Chinese Journal of Lasers

基　　金：国家重点研发计划(2017YFB1104300);国家自然科学基金(51775303,52075289)。

摘　　要：物质的结晶在生物制药、大分子结构分析等领域有着重要的应用,这些应用对结晶结果(包括晶体数量、大小、晶型等)提出了一定的需求,而通过蒸发溶剂或改变温度使溶质析出结晶的传统方法,存在结晶结果难以控制的问题。近年来,超快激光在调控晶体形核生长中的应用得到了关注和研究。超快激光以其超快、超强的特点,在调控晶体形核与生长方面具有独特的作用,且具有热影响区域小、适用材料范围广等优势。本文综述了超快激光调控晶体形核生长过程的研究进展,主要包括超快激光诱导结晶形核、控制晶体生长过程以及晶面图案化加工三个方面,并对超快激光调控晶体形核生长研究的应用前景进行了展望。Significance Crystallization has applications in biomedicine,structural analysis,and other related fields.For example,single crystal X-ray diffraction(XRD)is a common method for the structural analysis of biomacromolecules.Polymorph crystallization is also of significance in the pharmaceutical industry.These applications require the number,size,and polymorph of the crystals to be determined.Conventionally,crystals are obtained by evaporation of a solution or via a batch cooling process.However,the complex nature of the crystallization process means that precise control of crystallization is difficult.The crystallization process consists of two main stages:nucleation and crystal growth.When the concentration of a solute exceeds its solubility,the supersaturated solution is in a metastable zone.When the solute concentration reaches the supersaturation limit,nucleation occurs.The nucleus will then grow into larger crystals when the concentration drops back to the solubility level.In recent years,various methods have been studied for controlling crystal nucleation and growth processes,including those involving lasers,ultrasonics,and electromagnetic fields(Table 1,Table 2).Among these methods,ultrafast laser,because of its ultrashort pulse width and ultrahigh peak intensity,interacts uniquely with the solution and crystals.It has advantages including limited thermal effects and can be applied to many materials.Therefore,the ultrafast laser method has been applied for the control of the crystallization process.In this review,we introduce the research progress of ultrafast laser-controlled crystallization.Many different methods and mechanisms of laser-induced nucleation and crystallization are discussed.Studies on effective control of the crystallization process will not only benefit the biomedical industry,but also shed new light on current academic crystallography research.Progress The ultrafast laser-controlled crystallization process can be categorized into several different types depending on stage of crystallizati

关 键 词：激光技术 超快激光 结晶 形核 晶体生长 

分 类 号：TN249[电子电信—物理电子学]