Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue  

作　　者：Yan Zhang Qiying Lv Kai Chi Qilin Li Huiling Fan Bo Cai Fei Xiao Shuai Wang Zheng Wang Lin Wang 

机构地区：[1]Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Key Laboratory of Material Chemistry for Energy Conversion and Storage,Ministry of Education,Hubei Key Laboratory of Material Chemistry and Service Failure,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan,430074,China

出　　处：《Nano Research》2021年第5期1335-1343,共9页纳米研究（英文版）

基　　金：This work is supported by the National Natural Science Foundation of China(Nos.81572866,81773104,81773263,81873931,and 81974382);the China Postdoctoral Science Foundation(No.2019M652617);the National Key Basic Research Program of China(No.2015CB5540007).

摘　　要：The development of hierarchical nanostructure is demonstrated as an effective strategy to improve catalytic activity and stability of electrocatalysts.Herein,a novel leaf-like hierarchically porous heterojunction flake arrays(FAs),integrated graphitic N-doped carbon(NC)with amorphous B,N-doped carbon(BNC),has been designed and grown on flexible carbon fiber(CF)using metal-organic framework(MOF)FAs and green ionic liquids as precursors.The hierarchical heterojunction structure possesses micro-and nano-scaled pores,large surface areas,and exposed high-density catalytic active sites,which enhances electronic conductivity and offers accessible transport channels for effectively decreasing mass transport resistance.The results of discrete Fourier transform(DFT)calculations and experiments also suggest that the catalytic activity has been promoted by the heterojunction structure through narrowing the banding gap.Consequently,the resultant nanohybrid microelectrode exhibits remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 50 nM,and a high sensitivity of 213μA×mM-1×cm-2,as well as good anti-interference capability.The practical application of nanohybrid fiber microelectrode has been explored by real-time monitoring H2O2 released from live colon cells and surgically-resected fresh colon cancer tissue,which can provide important information for the identification of different types of cells as well as distinguish cancer cells from normal ones.We believe this research will pave the way towards the development of advanced carbon nanomaterials for application in the fields of electrochemistry,biosensing,and cancer diagnosis.

关 键 词：carbon heterojunction structure hierarchical flake arrays heteroatoms doping electrochemical sensor cancer biomarker detection 

分 类 号：O646[理学—物理化学]