Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots  

作　　者：Leela Goel Huaiyu Wu Bohua Zhang Jinwook Kim Paul A.Dayton Zhen Xu Xiaoning Jiang 

机构地区：[1]Department of Mechanical&Aerospace Engineering,North Carolina State University,Raleigh,NC 27695,USA [2]The Joint Department of Biomedical Engineering,The University of North Carolina at Chapel Hill and North Carolina State University,Chapel Hill,NC 27599,USA [3]Department of Biomedical Engineering,University of Michigan,Ann Arbor,MI 48109,USA

出　　处：《Microsystems & Nanoengineering》2021年第1期77-83,共7页微系统与纳米工程（英文）

基　　金：supported by National Institutes of Health grant R01HL141967。

摘　　要：One major challenge in current microbubble(MB)and tissue plasminogen activator(tPA)-mediated sonothrombolysis techniques is effectively treating retracted blood clots,owing to the high density and low porosity of retracted clots.Nanodroplets(NDs)have the potential to enhance retracted clot lysis owing to their small size and ability to penetrate into retracted clots to enhance drug delivery.For the first time,we demonstrate that a sub-megahertz,forwardviewing intravascular(FVI)transducer can be used for ND-mediated sonothrombolysis,in vitro.In this study,we determined the minimum peak negative pressure to induce cavitation with low-boiling point phase change nanodroplets and clot lysis.We then compared nanodroplet mediated sonothrombolysis to MB and tPA mediate techniques.The clot lysis as a percent mass decrease in retracted clots was 9±8%,9±5%,16±5%,14±9%,17±9%,30±8%,and 40±9%for the control group,tPA alone,tPA+US,MB+US,MB+tPA+US,ND+US,and ND+tPA+US groups,respectively.In retracted blood clots,combined ND-and tPA-mediated sonothrombolysis was able to significantly enhance retracted clot lysis compared with traditional MB and tPA-mediated sonothrombolysis techniques.Combined nanodroplet with tPA-mediated sonothrombolysis may provide a feasible strategy for safely treating retracted clots.

关 键 词：THROMBOLYSIS directed BOILING 

分 类 号：R318[医药卫生—生物医学工程]