石家庄市布鲁杆菌病流行病学特征及其临床分离株对常用抗菌药物的敏感性分析  

Analysis on epidemiological characteristics of brucellosis and sensitivity of clinical isolates to commonly used antibacterials in Shijiazhuang City

作　　者：张志[1] 高会霞[1] 田岳飏[1] 李砚峰 戴二黑[1] ZHANG Zhi;GAO Hui-xia;TIAN Yue-yang;LI Yan-feng;DAI Er-hei(Laboratory Department,Fifth Hospital of Shijiazhuang City,Shijiazhuang Hebei,050021,China)

机构地区：[1]石家庄市第五医院检验科,河北石家庄050021

出　　处：《职业与健康》2021年第3期411-414,共4页Occupation and Health

基　　金：河北省医学科学研究重点课题(20191451)。

摘　　要：目的分析石家庄市布鲁杆菌病(布病)的流行病学特征及其临床分离株对常用抗菌药物的敏感性,为制定防治布病的措施提供参考依据。方法以2016年1月1日—2018年12月31日石家庄市第五医院收治的布病患者共219例为调查对象,进行描述流行病学分析,并且对分离出的布鲁杆菌进行药敏试验。结果石家庄市布病多发于每年的3—7月,3—12月发病人数分别为20、34、33、30、25、14、11、11、5和6例。发病区域以石家庄北部地区居多,发病人群主要是牛羊养殖户和农民;药敏试验显示分离出的布鲁杆菌对多粘菌素B 123株(100.00%耐药)、青霉素G 35株(28.46%耐药)以及红霉素28株(22.76%耐药)存在不同程度的耐药。结论石家庄市布病的防控应以每年3—7月、北部地区、牛羊养殖户和农民为主。同时,在治疗时应加强对抗菌药物多粘菌素B、青霉素G和红霉素的管理。Objective To analyze the epidemiological characteristics of brucellosis in Shijiazhuang City and the sensitivity of clinical isolates to commonly used antibacterial drugs, provide a basis for formulating measures to prevent and treat brucellosis.Methods A total of 219 brucellosis patients who were treated in the Fifth Hospital of Shijiazhuang from January 1, 2016 to December 31, 2018 were investigated for epidemiological study. Drug sensitivity test was performed on the Brucella strains isolated from the patients. Results Brucellosis in Shijiazhuang City occurred frequently from March to July each year, and the number of cases from March to December was 20, 34, 33, 30, 25, 14, 11, 11, 5 and 6, respectively. The epidemic area was mostly in the northern area of Shijiazhuang, and the population was mainly cattle and sheep farmers and farmers. The drug susceptibility tests showed that the isolated Brucella had different degrees of drug resistance to polymyxin B(123 strain, drug resistance of 100.00%), penicillin G(35 strain, drug resistance of 28.46%), and erythromycin(28 strain, drug resistance of 22. 76 %).Conclusion The prevention and control of brucellosis in Shijiazhuang City should be mainly from March to July every year, and focus on cattle and sheep farmers and farmers in the northern region. At the same time, it is necessary to strengthen the rational use of antibacterial drugs in the treatment, such as polymyxin B, penicillin G and erythromycin.

关 键 词：布鲁杆菌 布鲁杆菌病 流行病学特征 药敏试验 

分 类 号：R183[医药卫生—流行病学]