CD47与动脉粥硬化相关性研究进展  

Research progress on the relationship between CD47 and atherosclerosis

作　　者：吴晨霞 吕铮天 李心怡 周鑫斌[1] 毛威[1] WU Chen-xia;LYU Zheng-tian;LI Xin-yi;ZHOU Xing-bin;MAO Wei(Department of Cardiology,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310060,China)

机构地区：[1]浙江中医药大学附属第一医院心内科,浙江省杭州市310060

出　　处：《中国心血管病研究》2021年第3期265-268,共4页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金(81673706)。

摘　　要：急性心肌梗死、卒中已成为我国非传染疾病死亡的首要原因,动脉粥样硬化是其重要病理生理基础。积极寻找缓解动脉粥样硬化的有效策略已刻不容缓。近年来发现CD47参与动脉粥样硬化发生发展过程中的免疫反应和凋亡小体清除等。CD47阻断剂干预可显著缓解动脉粥样硬化。本文将综述CD47在动脉粥样硬化中发挥作用的已知机制以及由此带来的进展,以期为临床干预提供治疗靶点,为冠心病患者提供个性化治疗方案。Heart attack and stroke have become the leading cause of noncommunicable disease mortality in China.And atherosclerosis is the major pathological basis in various cardiovascular diseases.Actively looking for the effective strategies to alleviate atherosclerosis is urgent.It has been found that CD47 is involved in immune response and the removal of apoptotic bodies during the development of atherosclerosis in recent years.CD47 blocker intervention can significantly relieve atherosclerosis.This article reviews the known mechanisms of CD47’s role in atherosclerosis and the progress it brings,with a view to providing therapeutic targets for clinical interventions and personalized treatment options for patients with coronary heart disease.

关 键 词：动脉粥样硬化 CD47 炎症 凋亡小体 

分 类 号：R541.4[医药卫生—心血管疾病]