抗反流胆道支架研究现状及进展  

Research Progress of Anti-Reflux Biliary Stent

作　　者：王越 宋晓菲 徐新生[2] WANG Yue;SONG Xiaofei;XU Xinsheng(Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education,School of Mechanical Engineering,Tianjin University,Tianjin 300350,China;Department of Hepatopancreatobiliary Surgery,Tianjin Nankai Hospital,Tianjin 300100,China)

机构地区：[1]天津大学机械工程学院,机构理论与装备设计教育部重点实验室,天津300350 [2]天津市南开医院肝胆胰外科,天津300100

出　　处：《医用生物力学》2021年第1期158-163,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(51875404);天津市自然科学基金项目(18JCYBJC19700)。

摘　　要：胆道支架是治疗恶性胆道梗阻的有效手段,而常规胆道支架术后普遍存在肠胆反流,从而引发胆道逆行感染、支架堵塞等并发症,严重降低了患者生存质量。目前,抗反流胆道支架被认为是兼顾引流与抑制肠胆反流功能的具有前景的姑息性治疗手段。对抗反流胆道支架的研究现状进行综述,重点对抗反流瓣膜的功能设计与评估、瓣膜与本体支架连接设计、抗反流胆道支架生物力学问题等方面进行概述总结,并对抗反流胆道支架的当前研究进展与趋势进行总结与分析。Biliary stent is an effective method for treating malignant biliary obstruction. However,duodenobiliary reflux is commonly found after conventional biliary stent,which causes complications such as biliary retrograde infection and stent blockage,and seriously reduces the quality of patients’ life. At present,anti-reflux biliary stent is considered as a promising palliative treatment method taking drainage and preventing duodenobiliary reflux into account. In this paper,research status of anti-reflux biliary stent was reviewed,and key problems such as design and evaluation of anti-reflux valve,valve and stent connection design,biomechanical analysis of anti-reflux biliary stent were mainly summarized. The current research progress and trend of anti-reflux biliary stent were summarized and analyzed.

关 键 词：胆道支架 肠胆反流 抗反流 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程]