2008-2017年中国CHINET肠球菌属细菌耐药性监测  

Surveillance of resistance of CHINET Enterococcus bacteria in China from 2008 to 2017

作　　者：谭枝微 顾兵 TAN Zhiwei;GU Bing(School of Medical Technology,Xuzhou Medical University,Xuzhou 221004;Clinical Laboratory,Siyang People’s Hospital,Siyang 223700;Clinical Laboratory,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学医学技术学院,江苏徐州221004 [2]泗阳县人民医院检验科,江苏泗阳223700 [3]徐州医科大学附属医院检验科,江苏徐州221002

出　　处：《南京医科大学学报（自然科学版）》2021年第1期65-68,73,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81871734);江苏省卫生计生委科研项目(H201631)。

摘　　要：目的:总结2008-2017年中国细菌耐药监测网CHINET中肠球菌属的检出情况和对不同抗菌药物的耐药性变迁。方法:各医院按统一方案,采用统一的材料、方法和判断标准进行肠球菌属的耐药性监测,通过CHINET细菌耐药性监测网对2008-2017年监测数据进行汇总分析。结果:2008-2017年共分离到71 743株非重复肠球菌属细菌,包括屎肠球菌(48.0%)、粪肠球菌(44.8%)、其他肠球菌(7.2%)。10年间,肠球菌属细菌的检出率在7.0%~8.9%波动,万古霉素耐药粪肠球菌和屎肠球菌检出率分别为0.1%、1.2%。粪肠球菌对红霉素和利福平的耐药率在50%以上,对其他药物耐药率均在50%以下,屎肠球菌对氨苄西林、红霉素、环丙沙星的耐药率高达87%以上,10年来粪肠球菌和屎肠球菌对不同抗菌药物的耐药率在各年份间的差异有统计学意义(P <0.05)。结论:10年间肠球菌和耐万古霉素肠球菌的检出情况稳定,对各种抗菌药物的耐药率总体有下降趋势,但耐利奈唑胺肠球菌的检出率逐渐升高,应引起重视。Objective:To summarize the detection of Enterococcus in China’s bacterial resistance surveillance network CHINET from 2008 to 2017 and the changes of resistance to different antimicrobial agents. Methods:CHlNET bacterial resistance monitoring network each hospital carried out the surveillance of Enterococcus drug resistance according to the unified program,uniform materials,methods(K-B method)and judgment criteria. Results:From 2008 to 2017,a total of 71 743 bacteria of the genus Enterococcus were isolated,including E. faecium(48.0%),E. faecalis(44.8%)and others(7.2%). Within 10 years,the detection rate of Enterococcus fluctuated between 7.0% and 8.9%,the detection rates of vancomycin-resistant E. faecalis was 0.1% and E. faecium was 1.2%. The resistance rates of E. faecium to erythromycin and rifampicin were more than 50%,and those to other drugs were less than 50%,The resistance rates of E.faecalis to ampicillin,erythromycin and ciprofloxacin were more than 87%,There was no difference in the drug resistance rates between the two drugs in the past 10 years(P < 0.05). Conclusion:In the past ten years,the detection of Enterococcus and vancomycin-resistant Enterococcu was stable,and the resistance rate to all kinds of antibacterial drugs has a downward trend,but the detection rate of linezolid-resistant Enterococcus has gradually increased,which should be paid attention to.

关 键 词：肠球菌 耐药性监测 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]