抗生素药物抗体与易感基因研究进展  

Research progress of antibiotic drug antibodies and susceptibility genes

作　　者：叶水文[1] 饶美英[1] 余玲 YE Shuiwen;RAO Meiying;YU Ling(Department of Blood Transfusion,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院输血科,江西南昌330006

出　　处：《南京医科大学学报（自然科学版）》2021年第1期135-140,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江西省卫生健康委科技计划(20204233)。

摘　　要：近年来,抗生素不合理使用造成的包括过敏、耐药抗药、溶血等不良反应已成为威胁人类健康的全球性问题,诸多国家均严格控制抗生素用量,避免不必要的抗生素使用,以减轻在全球范围内传播的耐药抗药问题。同时,对抗生素药物抗体易感基因的筛查与鉴定成为克服抗生素不良反应的关键。文章对近年来国内外抗生素使用情况、不良反应、抗生素药物抗体易感性与易感基因的关系、药物抗体易感基因筛查鉴定等方面的研究进展进行综述,对于今后我国抗生素类药物临床使用和用药预警、抗生素抗体易感基因研究等具有重要意义。In recent years,the adverse reactions caused by irrational use of antibiotics,including allergy,drug resistance and hemolysis,have become a global problem threatening human health. Many countries strictly control the use of antibiotics to avoid unnecessary use of antibiotics,so as to reduce the spread of drug-resistant and drug-resistant problems in the world. At the same time,screening and identification of antibiotic susceptibility genes is the key to overcome the adverse reactions of antibiotics. This paper reviews the research progress of antibiotic use,adverse reactions(ADR),the relationship between antibiotic susceptibility and susceptibility genes,screening and identification of drug antibody susceptibility genes in recent years,which is of great significance for the clinical use and early warning of antibiotics,and the research of antibiotic antibody susceptibility genes in China.

关 键 词：抗生素 药物抗体 易感基因 疾病防治 

分 类 号：R978.1[医药卫生—药品]