新型肌肉松弛药拮抗剂舒更葡糖钠在麻醉苏醒期应用的近况  

Recent application of sugammadsx in the recovery period after anesthesia

作　　者：曹婷婷 顾娟[1] Cao Tingting;Gu Juan(Department of Anesthesiology,Renji Hospital Affiliated to Medical College of Shanghai Jiao Tong University,Shanghai 200127)

机构地区：[1]上海交通大学医学院附属仁济医院麻醉科,200127

出　　处：《国际麻醉学与复苏杂志》2021年第2期186-190,共5页International Journal of Anesthesiology and Resuscitation

摘　　要：舒更葡糖钠是拮抗非去极化肌肉松弛药(肌松药)的新型药物,它能够快速、安全、可控地拮抗罗库溴铵等甾体类肌松药的神经肌肉阻滞,与传统肌松拮抗剂抗胆碱酯酶药相比,具有拮抗深度神经肌肉阻滞且不影响胆碱能系统活性的优越性,在麻醉苏醒期的临床应用具有广泛前景。文章通过对新型肌松拮抗药舒更葡糖钠的作用机制、使用效能、在特殊患者中的应用、神经肌肉阻滞残余、再箭毒化情况和不良反应等几方面进行综述,从而帮助麻醉医师在临床中更加合理地使用舒更葡糖钠,提高患者麻醉后苏醒期的质量。Sugammadsx sodium injection is a new antagonist against non-depolarizing muscle relaxants.It can quickly,safely and controllably antagonize the neuromuscular blockage of steroidal muscle relaxants such as rocuronium.Compared with traditional muscle antagonists like anticholinesterase,it is highly antagonistic to nerve muscle blockage,without effects on the cholinergic system,and may be widely used in the recovery period after anesthesia.The current review focuses on the following aspect of sugammadsx:mechanism of action,efficacy,its use in special patients,neuromuscular block residual and re-arrow poisoning,and adverse reactions,so as to provide evidence for rational use and improve the quality of recovery after anesthesia.

关 键 词：肌肉松弛药 拮抗剂 舒更葡糖钠 麻醉苏醒期 

分 类 号：R614[医药卫生—麻醉学]