促性腺激素释放激素激动剂垂体降调节后多卵泡发育的病例分析及文献复习  

Case analysis and literature review on multiple ovarian follicles growed after pituitary down-regulation by gonadotropin-releasing hormone agonist

作　　者：王爽[1] 张宁[1] 赵冬梅[1] 王梅梅 Wang Shuang;Zhang Ning;Zhao Dongmei;Wang Meimei(Reproductive Medicine Center,Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院生殖医学科,264000

出　　处：《中华生殖与避孕杂志》2021年第2期154-158,共5页Chinese Journal of Reproduction and Contraception

摘　　要：目的结合既往临床病例及文献复习,总结促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonist,GnRH-a)垂体降调节后多卵泡发育的诊疗特征。方法报道1例于本院应用GnRH-a垂体降调节后多卵泡发育的患者情况,并结合中外文献报道的16例个案的病例特点进行回顾性分析。结果应用GnRH-a后发生多卵泡发育的情况,目前无法预测亦无法避免。应用GnRH-a后的“flare-up”效应和卵泡刺激素受体基因的突变可能是发病原因。结论GnRH-a垂体降调节后多卵泡发育可行取卵手术,建议新鲜周期全部胚胎冷冻,择期行冻融胚胎移植。Objective To summarize the diagnosis and treatment characteristics of multiple ovarian follicles growed after pituitary downregulation by gonadotropin-releasing hormone agonist(GnRH-a).Methods This paper reported one patient with multiple ovarian follicles growed after pituitary downregulation using GnRH-a in our hospital,and the characteristics of 16 cases reported in Chinese and foreign literatures were retrospectively analyzed.Results It is difficult to predict and avoid the development of multiple ovarian follicles after application of GnRH-a,and the"flare-up"effect after application of GnRH-a and the mutation of follicle-stimulating hormone(FSH)receptor gene may be the cause of the disease.Conclusion The oocyte extraction operation is feasible for multiple ovarian follicles growed after pituitary downregulation.It is suggested to freeze the whole embryos in fresh cycle,and conducted embryo thawing transplantation at another time.

关 键 词：受精 体外 胚胎移植 垂体降调节 促性腺激素释放激素激动剂 

分 类 号：R714.8[医药卫生—妇产科学]