提壶揭盖法治疗糖尿病合并便秘的临床疗效及对患者血清SP、NO水平的影响  

Clinical Effect of Tihu Jiegai Method for Diabetes Complicated with Constipation and Its Effect on Levels of SP and NO in Serum

作　　者：陆喜荣[1] 戴彦苗 胡芸[1] 陶鸣浩[1] 徐进康[1] 杨炜[1] LU Xirong;DAI Yanmiao;HU Yun;TAO Minghao;XU Jinkang;YANG Wei

机构地区：[1]南京中医药大学附属昆山市中医院,江苏昆山215300

出　　处：《新中医》2021年第5期87-90,共4页New Chinese Medicine

基　　金：2017年全国基层名老中医药专家传承工作室项目(国中医药人教教育便函[2017]156号);第二批江苏省中医药领军人才项目(苏中医科教[2018]4号)。

摘　　要：目的:观察提壶揭盖法治疗糖尿病合并便秘的临床疗效及对患者血清P物质(SP)、一氧化氮(NO)水平的影响。方法:选取70例糖尿病合并便秘患者,按随机数字表法分为治疗组和对照组,每组35例,治疗期间2组共脱落3例,最终纳入治疗组34例,对照组33例。治疗组在常规降血糖基础上基于提壶揭盖法组方治疗,对照组在常规降血糖基础上给予乳果糖联合枸橼酸莫沙必利治疗,2组均连续治疗8周。比较2组临床疗效、症状积分、排便情况、心理状态及血清SP、NO水平。结果:治疗组愈显率为91.18%,高于对照组的72.73%(P<0.05)。治疗后,2组大便干结、排便不畅、腹胀、里急后重及腹痛积分均较治疗前降低(P<0.05),治疗组大便干结、排便不畅、腹胀、里急后重及腹痛积分均低于对照组(P<0.05)。与治疗前比较,治疗后2组排便时间均缩短,排便频率均降低,大便性状均有改善(P<0.05);治疗组排便时间短于对照组,排便频率低于对照组,大便性状改善情况优于对照组(P<0.05)。治疗后,2组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均较治疗前降低(P<0.05),治疗组SAS、SDS评分均低于对照组(P<0.05)。治疗后,2组血清SP水平均较治疗前升高,血清NO水平均较治疗前降低(P<0.05);治疗组血清SP水平高于对照组,血清NO水平低于对照组(P<0.05)。结论:基于提壶揭盖法治疗糖尿病合并便秘,可以较好地改善患者的临床症状,改善其肠道动力及心理状态,促进排便。Objective:To observe the clinical effect of Tihu Jiegai method for diabetes complicated with constipation and its effect on levels of substance P(SP) and nitric oxide(NO) in serum. Methods:A total of 70 cases of patients with diabetes complicated with constipation were selected, and divided into the treatment group and the control group according to the random number table method,35 cases in each group. During treatment,three patients discontinued the study in the two groups. Finally,a total of 34 cases were enrolled in the treatment group,and 33 cases in the control group. The treatment group was given prescriptions based on Tihu Jiegai method, and the control group was given lactulose combined with mosapride citrate. Both groups were continuously treated for eight weeks. The clinical effect,symptom scores,defecation,mental state,as well as levels of SP and NO in serum were compared between the two groups. Results:The cured and markedly effective rate was 91.18% in the treatment group,higher than that of 72.73% in the control group(P<0.05). After treatment,scores of dry stool,poor defecation,abdominal distension,tenesmus,and abdominal pain in the two groups were decreased when compared with those before treatment(P<0.05),and the scores above in the treatment group were lower than those in the control group(P<0.05). After treatment,the defecation time in the two groups was shortened when compared with that before treatment,defecation frequency was reduced,and stool characteristics were improved(P<0.05).After treatment,the defecation time in the treatment group was earlier than that in the control group,defecation frequency was lower,and the improvement of stool characteristics was better(P<0.05). After treatment,scores of Self-Rating Anxiety Scale(SAS) and Self-Rating Depression Scale(SDS) in the two groups were decreased when compared with those before treatment(P<0.05),and the two scores in the treatment group were lower than those in the control group(P<0.05). After treatment,SP levels in serum in the two grou

关 键 词：糖尿病 便秘 提壶揭盖法 焦虑 抑郁 P物质 一氧化氮 

分 类 号：R587.1[医药卫生—内分泌] R256.35[医药卫生—内科学]