PM2.5暴露与妊娠期高血压疾病的Meta分析  

A Meta-analysis of ambient fine particulate matter pollution and hypertensive disorders of pregnancy

作　　者：杨越 朱启英[1] 武建利[1] YANG Yue;ZHU Qiying;WU Jianli(Maternal and Fetal Medical Center,Department of Obstetrics,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830021,China)

机构地区：[1]新疆医科大学第一附属医院母胎医学中心产科,新疆乌鲁木齐830021

出　　处：《中国优生与遗传杂志》2021年第1期58-63,共6页Chinese Journal of Birth Health & Heredity

基　　金：新疆维吾尔自治区自然科学基金(2017D01C317)。

摘　　要：目的本研究希望通过研究PM2.5暴露与不良妊娠结局二者暴露-定量关系,揭示PM2.5暴露能否可能增加患妊娠期高血压疾病的风险,并判定是否存在更高危的暴露时间窗。方法利用计算机检索文献,以妊娠期高血压疾病为观察结局,采用Cochrane协作网系统评价方法筛选文献,用Stata12.0软件对符合标准纳入的文献进行Meta分析。结果 Meta分析一共纳入12篇文献。基于妊娠全期暴露,PM2.5浓度每增加10μg/m3与妊娠期高血压疾病(OR=1.26;95%CI:1.26~1.74;P<0.01)相关;基于妊娠各期暴露,妊娠早、中、后期PM2.5暴露浓度每升高10mg/m3,妊娠期高血压疾病的风险分别为1.11(1.04~1.17)、1.13(1.06~1.21)和1.14(0.90~1.45)。敏感性分析发现研究结果稳定可靠,但可能存在一定的发表偏倚。结论PM2.5妊娠期的暴露增加妊娠期高血压疾病的风险,且妊娠早期、妊娠中期可能为更高危的暴露时间窗。Objective This study aims at conducting a meta-analysis to synthetically quantify the exposure-dose quantitative relationship between PM2.5 exposure and hypertensive disorders of pregnancy as well as establishing whether PM2.5 exposure can lead to increased risk of adverse pregnancy outcomes, and providing evidence for if exposure has higher risky pregnancy period. Methods The literatures were retrieved by computer, using the Cochrane Collaboration network system evaluation method to obtain all papers which studying on quantitative relationship bewteen PM2.5 exposure measurement and hypertensive disorders of pregnancy. We choose hypertensive disorders of pregnancy as the outcome of observation. Using Stata 12.0 Meta-analysis software to explore the quantitative relationship and do the meta ananlysis. Results A total of 12 articles were included for meta-analysis. Based on exposure throughout pregnancy, every increase in PM2.5 concentration of 10 μg/m3 was associated with hypertension disorder of pregnancy(OR=1.26;95%CI: 1.26–1.74;P<0.01);based on pregnancy period of exposure, for every 10 μg/m3 increase in PM2.5 exposure in first, second, and third trimester, the risk of hypertension disorder of pregnancy is 1.11(1.04–1.17), 1.13(1.06–1.21), and 1.14(0.90–1.45). Sensitivity analysis found that the research results obtained were relatively stable and reliable, but the analysis suggested that there might be a publication bias. Conclusion Exposure to PM2.5 during pregnancy may increase the risk of hypertension disorders of pregnancy, and first trimester and second trimester may be a higher risk exposure window.

关 键 词：META分析 PM2.5 妊娠期高血压疾病 妊娠期高血压 子痫前期 

分 类 号：R714.246[医药卫生—妇产科学]