环己酮氨肟化反应分离耦合工艺研究  

Study on reaction-separation coupling processes for cyclohexanone ammoximation

作　　者：刘建武[1,2] 汪伟伟 严生虎 沈介发[1,2] 张跃 LIU Jian-wu;WANG Wei-wei;YAN Sheng-hu;SHEN Jie-fa;ZHANG Yue(School of Pharmaceutical Engineering&Life Science,Changzhou University,Changzhou 213164,China;Continuous Flow Engineering Laboratory of National Petroleum and Chemical Industry,Changzhou 213164,China)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164 [2]石油和化工行业连续流技术工程实验室,江苏常州213164

出　　处：《现代化工》2021年第3期207-210,共4页Modern Chemical Industry

基　　金：江苏省产学研前瞻性联合研究项目(BY2014037-19)。

摘　　要：研究设计了一种环己酮氨肟化反应-沉降分离耦合装置,通过TS-1的絮凝沉降解决了TS-1与反应液的分离问题。分别考察了沉降时间、物料摩尔比、反应温度和停留时间对TS-1沉降效率的影响,优化了工艺条件。结果表明,在n(H_(2)O_(2))∶n(环己酮)=1.0、n(氨水)∶n(环己酮)=1.8、反应温度70℃、沉降时间6.5 min、停留时间70 min时,可以维持反应体系的稳定,TS-1进行正常的沉降分离,此时料液中TS-1质量分数降低至0.4386‰,环己酮的转化率和环己酮肟的选择性分别达到96.7%和99.6%。A kind of reaction-separation coupling device is designed for cyclohexanone ammoximation.Separation of TS-1 and reaction liquid is settled through flocculation and sedimentation of TS-1 in this device.The effects of sedimentation time,reactants molar ratio,reaction temperature and residence time on reactant conversion,product selectivity and TS-1 sedimentation efficiency are investigated,and the process conditions are optimized.Ahe conversion of cyclohexanone reaches 96.7%,the selectivity of cyclohexanone oxime reaches 99.6%,and the TS-1 concentration in overflow liquid reduces 0.4386‰ as n(H_(2)O_(2))∶n(cyclohexanone)=1.0∶1,n(NH_(3)H_(2)O)∶n(cyclohexanone)=1.8∶1,reaction temperature maintains at 70℃,residence lasts for 70 min and sedimentation lasts for 6.5 min.

关 键 词：反应分离耦合 氨肟化 TS-1 环己酮 

分 类 号：TQ426[化学工程]