新型冠状病毒肺炎的病理学特征  

Pathological characteristics of COVID-19

作　　者：魏胜兵 王金萍 罗雪 王亮[2] 李庆昌[2] 邱雪杉[2] 王恩华[2] WEI Sheng-bing;WANG Jin-ping;LUO Xue;WANG Liang;LI Qing-chang;QIU Xue-shan;WANG En-hua(Shenyang King Med Center for Clinical Laboratory Co.,Ltd.,Shenyang 110164;Department of Pathology,College of Basic Medical Science,China Medical University,Shenyang 110122,China)

机构地区：[1]沈阳金域医学检验所有限公司,辽宁沈阳110164 [2]中国医科大学基础医学院病理学教研室,辽宁沈阳110122

出　　处：《解剖科学进展》2021年第1期125-128,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81874214);辽宁省科技厅社发攻关及产业化资助项目(2017225010)。

摘　　要：新型冠状病毒病19(COVID-19)感染引起全身严重疾病并伴有肺功能不全。本文对近期发表的61例患者的病理学观察结果进行总结,发现肺脏组织学特征为:急性期弥漫性肺泡损伤、肺水肿、肺透明膜形成、弥漫性肺泡损伤、蛋白和纤维蛋白渗出,可见多核肺细胞;大多数病例有不同程度出血和血栓形成;浸润以淋巴细胞和单核细胞为主;免疫组化和电镜结果均显示Ⅱ型肺泡上皮细胞受损增生,其细胞胞浆和肺泡含有冠状病毒阳性成分。心脏、肝脏、肾和脾未见明显特征性病理改变。Coronavirus disease 19(COVID-19)infection causes severe systemic diseases with pulmonary insufficiency.The recently published pathological observation of 61 patients were summarized.The histological features of the lung include diffuse alveolar damage,pulmonary edema,hyaline membrane formation,diffuse alveolar injury,protein and fibrin exudation,and multinucleated lung cells.Most cases had bleeding and thrombosis in varying degrees,the infiltrations were mainly lymphocytes and monocytes.The results of immunohistochemistry and electron microscopy showed that type II alveolar epithelial cells were damaged and proliferated,and the cytoplasm and alveoli contained coronavirus positive components.No obvious pathological changes were found in heart,liver,kidney and spleen.

关 键 词：肺功能不全 纤维蛋白渗出 细胞胞浆 血栓形成 病理学观察 组织学特征 病理学特征 肺细胞 

分 类 号：R563.1[医药卫生—呼吸系统]