治疗中风后认知功能障碍电针刺激参数的数据挖掘研究  

Study on data mining of electroacupuncture stimulation parameters in the treatment of post-stroke cognitive dysfunction

作　　者：徐敏杰 谭逸海 李晓琳 李昌明 徐基民[2] 李艳丽[2] 常静玲[3] XU Minjie;TAN Yihai;LI Xiaolin;LI Changming;XU Jimin;LI Yanli;CHANG Jingling(Beijing University of Chinese Medicine,Beijing,100029,China)

机构地区：[1]北京中医药大学,100029 [2]中国康复研究中心,北京博爱医院中医康复科 [3]北京中医药大学东直门医院脑病科

出　　处：《环球中医药》2021年第4期594-601,共8页Global Traditional Chinese Medicine

基　　金：北京自然科学基金重点项目(7181005);中央高校校级重点攻关项目(2020-JYB-ZDGG-110-2)。

摘　　要：目的通过数据挖掘及可视化技术总结电针治疗中风后认知功能障碍常用的刺激参数,为今后针刺技术转化,最佳刺激参数选择提供依据。方法检索中、英文数据库,筛选合格文献,用Endnote X7进行文献管理,提取电刺激参数数据,采用EXCEL进行频数分析,采用R语言软件Aprior算法、离差平方和法聚类算法进行关联分析、聚类分析及可视化分析,探索临床选穴和电针刺激参数规律。结果所纳文献87篇,最常使用的电针刺激参数为:G6805型电针治疗仪,疏密波,低频,强度耐受,30分钟/次、1次/天、5次/周、观察时间28天,共使用腧穴69个,频率最高前5位分别是百会、神庭、四神聪、风池、本神,归经最高前5位为督脉、足少阳胆经、经外奇穴、足太阳膀胱经、足阳明胃经。聚类分析得出13类有效聚类群,关联规则分析支持度最高的为百会、四神聪、本神—风池,百会—神门,足三里—百会。结论电针治疗中风后认知功能障碍临床试验数据完整度不够,应通过进一步研究总结电针刺激治疗参数,为优化针刺治疗方案提供指导,推动治疗中风后认知功能障碍的中医特色康复技术形成,促进中医治疗设备转化。Objective To summarize the stimulation parameters commonly used in electroacupuncture treating post-stroke cognitive dysfunction by data mining and visualization techniques,so as to provide basis for the future acupuncture technology transformation and the selection of optimal stimulation parameters.Methods Chinese and English databases were searched,and qualified literature were screened.Endnote X7 was used for literature management and electrical stimulation parameter data was extracted.Excel was used for frequency analysis.The Aprior algorithm of R language software and the clustering algorithm of deviation square sum method were used for correlation analysis,clustering analysis and visual analysis,and the law of clinical acupoint selection and electroacupuncture stimulation parameters were explored.Results A total of 87 references were included,The most commonly used electroacupuncture stimulation parameters were:G6805 type electroacupuncture therapy instrument,dilatational wave,low frequency,tolerance intensity,30 minutes each time,one time each day,5 times each week,and the observation time was 28 days.A total of 69 acupoints were used in the literature,the top five points were Baihui(GV20),Shenting(GV24),Sishencong(EX-HN1),Fengchi(GB20),Benshen(GB13).The top five meridians were governor channel,gallbladder channel,extraordinary point,bladder channel,stomach channel.Cluster analysis showed 13 effective clusters,and association rule analysis showed the highest level of support were GV20,EX-HN1,GB13-GB20,GV20-Shenmen(TF4),and Zusanli(ST36)-GV20.Conclusion The clinical trial data of electroacupuncture for the treatment of post-stroke cognitive dysfunction is not complete enough.Therefore,further studies should be conducted to summarize the treatment parameters of electroacupuncture stimulation,providing guidance for the optimization of acupuncture therapy,promoting the formation of rehabilitation technology with traditional Chinese medicine characteristics for the treatment of post-stroke cognitive dysfunction

关 键 词：中风后认知功能障碍 电针刺激参数 数据挖掘 关联分析 聚类分析 可视化分析 

分 类 号：R245[医药卫生—针灸推拿学]