膜突蛋白抗体及其相关炎性因子与急性冠状动脉综合征  

Moesin antibody and inflammatory factors and acute coronary syndrome

作　　者：杜峰 张伟[1] 毛华[2] 郭艳丽[2] DU Feng;ZHANG Wei;MAO Hua;GUO Yanli(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,510405,China;The First People’s Hospital in Guiyang)

机构地区：[1]广州中医药大学第一附属医院,广州510405 [2]贵阳市第一人民医院

出　　处：《临床心血管病杂志》2021年第2期110-113,共4页Journal of Clinical Cardiology

基　　金：贵州省科技厅科学技术基金项目(No:黔科合J字[2013]2015号);贵阳市科技局科技计划项目(No:筑科合[2018]1-26号);贵阳市高层次创新型青年卫生人才项目(No:【2017】筑卫科技合同字第008号);贵阳市人才创新创业资助项目(No:筑人才办合同字【2014】第12号)。

摘　　要：目的:探讨膜突蛋白抗体与炎性因子的相关性及其在急性冠状动脉综合征(ACS)中的作用。方法:入选经选择性冠状动脉造影(CAG)确诊为ACS患者150例,动脉粥样硬化症(AS)患者40例,对照组为同期健康体检者120例。采用酶联免疫吸附实验(ELISA)检测入选者血清中膜突蛋白抗体及相关炎性因子的阳性表达水平。结果:(1)膜突蛋白抗体阳性检出率ACS组为36%,AS组为25%,均高于对照组5%(P<0.01)。炎性因子阳性表达水平ACS组和AS组均较对照组显著增高,差异有统计学意义(P<0.01);ACS组炎性因子阳性表达水平高于AS组,差异有统计学意义(P<0.05)。(2)膜突蛋白抗体与相关炎性因子无相关性(P>0.05);(3)ACS未服用药物(调脂、抗血小板治疗)组膜突蛋白抗体阳性检出率较服药物组高,差异有统计学意义(P<0.01)。结论:(1)膜突蛋白抗体在ACS与AS中表达较高;(2)膜突蛋白抗体与炎性因子表达无相关性;(3)膜突蛋白抗体在药物干预下可下降。Objective: To detect moesin antibody and inflammatory factors in serum of patients with acute coronary syndrome(ACS). Methods: There were 150 ACS cases in ACS group, 40 atherosclerosis(AS) cases in AS group, and 120 cases of healthy persons as control. We detected serum positive level of moesin antibody and inflammatory factors using the enzyme-linked immunosorbent assay. Results:(1)moesin antibody-positive expression in ACS group was 34%, was 10% in AS group, and was 5% in control group(P<0.01). Inflammatory factors expression in ACS group or AS group were increased than control group(P<0.01). Inflammatory factors expression in ACS group exceeded AS group(P<0.05);(2)There was no relationship between moesin antibody and inflammatory factors in ACS group(P>0.01);(3) Moesin antibody expression increased significantly in ACS group without drugs(antithrombotic, anti-platelet thearpy) than the medication group(P<0.01). Conclusion:(1)Moesin antibody expression is relatively high in ACS group or AS group;(2)Moesin antibody has no connection with inflammatory factor expression;(3)Drug intervention can reduce the Moesin antibody expression.

关 键 词：急性冠状动脉综合征 膜突蛋白抗体 高敏C反应蛋白 肿瘤坏死因子-α 白细胞介素-6 白细胞介素-8 

分 类 号：R541.4[医药卫生—心血管疾病]