转基因植物疫苗应用于口服免疫途径的新进展  

Recent advances on the oral delivery mechanism of transgenic plant vaccines

作　　者：王真 李小兰 刘建国 Wang Zhen;Li Xiaolan;Liu Jianguo(School of Stomatological of Zunyi Medical University,Zunyi Guizhou 563099,China;Department of Stomatology,Nanchong General Hospital,Nanchong Sichuan 637000,China;Guizhou Province Key Laboratory of Oral Disease Research and Key Laboratory of Oral Disease Research,Zunyi Medical University,Zunyi Guizhou 563006,China)

机构地区：[1]遵义医科大学口腔医学院,贵州遵义563099 [2]南充市中心医院口腔科,四川南充637000 [3]遵义医科大学贵州省普通高等学校口腔疾病研究特色重点实验室暨遵义市口腔疾病研究重点实验室,贵州遵义563006

出　　处：《遵义医科大学学报》2021年第1期132-136,140,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81260614);贵州省教育厅成长计划项目(NO:黔教合KY字(2017)200)。

摘　　要：口服免疫是最理想的免疫途径,转基因植物疫苗在通过口服途径作用于胃肠道粘膜系统时,在免疫应答的作用机制、抗原的表达形式等多个方面具有明显的优势。采取不同的口服给药方案,转基因植物疫苗可用于免疫耐受的诱导和加强免疫反应等治疗,这为疾病的防治方法提供了新的思路。Oral immunization is the most ideal way of immunization.When transgenic plant vaccines act on the mucosal system of the gastrointestinal tract through oral routes,they have obvious advantages in terms of the mechanism of immune response and the expression of antigens.By adopting different oral administration schemes,genetical modified plant vaccines could be used to induce immune tolerance and enhance immune response,which provides new ideas for disease prevention and treatment methods.

关 键 词：转基因植物疫苗 粘膜免疫 口服给药 

分 类 号：R318[医药卫生—生物医学工程]