针灸联合激素替代疗法治疗围绝经期综合征临床研究  

Clinical Study on Acupuncture and Moxibustion Combined with Hormonal Replacement Therapy for Perimenopausal Syndrome

作　　者：魏若菡 阮婴丹 张晨虹[1] 杨心宇[1] WEI Ruohan;RUAN Yingdan;ZHANG Chenhong;YANG Xinyu

机构地区：[1]台州市第一人民医院妇产科,浙江台州318020 [2]台州市第一人民医院中医针灸科,浙江台州318020

出　　处：《新中医》2021年第6期97-100,共4页New Chinese Medicine

摘　　要：目的:观察针灸联合激素替代疗法治疗围绝经期综合征患者的临床疗效。方法:将围绝经期综合征患者60例随机分为观察组和对照组,各30例。对照组采用全量芬吗通片(2 mg∶2 mg∶10 mg)治疗,观察组采用针灸联合半量激素替代疗法芬吗通片(1 mg∶1 mg∶10 mg)治疗,4周为1个疗程,共治疗3个疗程。比较2组治疗前后汉密尔顿抑郁量表(HAMD)评分、改良Kupperman评分,促黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E2)水平变化。结果:治疗后4、8、12周,2组患者HAMD评分均较治疗前改善(P<0.05),且观察组评分改善较对照组更显著(P<0.05)。治疗后4、8、12周,2组患者改良Kupperman评分均较治疗前改善(P<0.05),且观察组评分改善较对照组更显著(P<0.05)。治疗后,2组血清LH、FSH及E2水平变化不大,组间及治疗前后比较,差异均无统计学意义(P>0.05)。结论:与全量激素替代治疗比较,针灸联合半量激素替代治疗可明显改善围绝经期综合征患者的临床症状,但在调节生殖激素水平方面并无优势。Objective: To observe the clinical effect of acupuncture and moxibustion combined with hormonal replacement therapy for patients with perimenopausal syndrome. Methods: A total of 60 cases of patients with perimenopausal syndrome were randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with full-dose femoston tablets(2 mg∶2 mg∶10 mg),and the observation group was treated with acupuncture and moxibustion combined with hormonal replacement therapy with half dosage of femoston tablets(1 mg∶1 mg∶10 mg). Both groups were treated for three courses,four weeks being a course. Before and after treatment,the changes in Hamilton Depression Scale(HAMD) scores,modified Kupperman scores and levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH) and estradiol(E2) in the two groups were compared. Results:At four,eight and twelve weeks after treatment respectively, HAMD scores in the two groups were improved when compared with those before treatment(P<0.05),and the improvement in the observation group was more significant than that in the control group(P<0.05). At four,eight and twelve weeks after treatment respectively,modified Kupperman scores in the two groups were improved when compared with those before treatment(P<0.05),and the improvement in the observation group was more significant than that in the control group(P<0.05). After treatment,the changes in the levels of LH,FSH and E2 in serum in the two groups were not significant;the comparison between the two groups as well as before and after treatment showed no significance in the difference(P>0.05). Conclusion: Compared with the full-dose hormonal replacement therapy, the application of acupuncture and moxibustion combined with half-dose hormonal replacement therapy can significantly improve the clinical symptoms of patients with perimenopausal syndrome. Though without advantage in the regulation of reproductive hormone levels.

关 键 词：围绝经期综合征 激素替代疗法 半量 针灸 生殖激素 

分 类 号：R711.75[医药卫生—妇产科学]