基于超临界流体技术制备药物制剂的研究进展  

Research progress in the preparation of pharmaceutical formulations based on supercritical fluid technology

作　　者：王琳 许大壮 代奇轩 楚成超 李东 刘刚[1,2] Lin Wang;Dazhuang Xu;Qixuan Dai;Chengchao Chu;Dong Li;Gang Liu(Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China;Key Laboratory of Spectrochemical Analysis&Instrumentation,Ministry of Education,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361105,China)

机构地区：[1]厦门大学公共卫生学院,分子影像暨转化医学研究中心,厦门361102 [2]厦门大学化学化工学院,谱学分析与仪器教育部重点实验室,厦门361105

出　　处：《科学通报》2021年第10期1187-1194,共8页Chinese Science Bulletin

基　　金：国家重点研发计划(2017YFA0205201);国家杰出青年科学基金(81925019)资助。

摘　　要：超临界流体是温度和压力同时高于其临界值的流体,兼具气体和液体双重性质.通过改变温度和压力可对流体的理化性质进行调节,从而实现有效的分离和化学反应.基于其独特性质,目前超临界流体已广泛应用在天然有机成分萃取、颗粒制造以及化学反应等领域,由此衍生出的技术统称为超临界流体技术.本篇综述着重介绍超临界流体技术在医药领域的应用,包括药物纳米粒子及纳米药物载体的制备、纳米酶的制备以及超稳定药物复合制剂的制备.介绍了其基本原理、重点工艺流程以及操作条件.最后对超临界流体技术在纳米药物工业化生产的前景进行展望.Supercritical fluid is a fluid whose temperature and pressure are both higher than its critical value(Pc and Tc).At the critical point,the physical and chemical properties of the fluid are very sensitive to slight changes in temperature or pressure.At present,supercritical fluid is widely used in various fields of healthcare,from which supercritical extraction technology,supercritical fluid microparticle technology,chemical reaction in supercritical fluid and so on are derived.CO_(2) is the most widely used supercritical fluid due to its low price,stable chemical properties and mild operating conditions.The critical pressure Pc of CO_(2) is 7.37 MPa,which has low requirements for equipment conditions.The critical temperature Tc is 304.2 K,which can realize supercritical fluid operation at room temperature and save energy.This paper reviews the application of supercritical fluid technology in the preparation of pharmaceutical formulations,focusing on the problems of pharmaceutical research and clinical translation.Compared with the traditional pharmaceutical methods,the preparation of pharmaceutical formulations by supercritical fluid technology has the inherent characteristics of high biological activity,high purity,less impurities,green and safe,environmentally friendly.It is a promising new process in the pharmaceutical industry and also attracts the interest of scientific researchers.This review also summarizes the latest research achievements in the preparation of pharmaceutical nanoparticles,nano-drug carriers,nano-enzymes and super-stable pharmaceutical compounds based on supercritical fluid technology,introduces its basic principles and advantages,and looks forward to the development prospect of supercritical fluid technology in the field of nano-medicine.The main challenges in the field of pharmaceuticals are low solubility and poor stability in vivo.In order to solve these problems,supercritical technology is used to prepare nano-drugs,such as gambogic acid particles and curcumin particles,featuring impr

关 键 词：超临界流体 纳米药物载体 药物递送 超稳定药物混合制剂 绿色制备 

分 类 号：TQ460.1[化学工程—制药化工]