我国HIV感染者合并感染HBV现况  

Prevalence of HBV co-infection in HIV-positive population in China:a systematic review and Meta-analysis

作　　者：曹阳 周明浩 翟祥军[3] Cao Yang;Zhou Minghao;Zhai Xiangjun(School of Public Health,Nanjing Medical University,Nanjing 211166,China;Jiangsu Provincial Health Commission,Nanjing 210008,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]南京医科大学公共卫生学院,211166 [2]江苏省卫生健康委员会,南京210008 [3]江苏省疾病预防控制中心,南京210009

出　　处：《中华流行病学杂志》2021年第2期327-334,共8页Chinese Journal of Epidemiology

基　　金：国家科技重大专项(2018ZX10715002)。

摘　　要：目的通过文献回顾,了解我国HIV感染者中HBV感染的流行特征。方法通过对2010-2019年文献检索、文献筛选、质量评价等过程,收集我国有关HIV感染者合并感染HBV的研究文献,对符合纳入标准的文献提取相关数据后进行Meta分析。结果共纳入27项研究,合并样本量为69816例;我国HIV感染者的HBV合并感染率为11.29%,西部地区(10.73%)和南部地区(14.18%)的合并感染率较高,北部地区(6.36%)最低;血液或血液制品传播、注射吸毒传播、同性性传播、异性性传播、传播途径不详和母婴传播的HIV感染者的HBV合并感染率分别为11.22%、12.76%、9.58%、11.32%、10.34%和2.87%。在HIV各种传播途径中,经母婴传播的HIV感染者的HBV合并感染率最低;南部地区男性HIV感染者的HBV感染率是女性的1.29倍。结论我国HIV感染者的HBV感染率明显高于普通人群的HBV感染率;应加强HIV/HBV共感染者的预防控制。Objective To reveal the epidemiologic characteristics of hepatitis B virus(HBV)infection in HIV positive population in China.Methods We collected research papers published from 2010 to 2019 on HBV co-infection in HIV positive population in China through literature retrieval,screening and quality evaluation.The Meta-analysis was conducted after extracting relevant data from the research papers meeting the inclusion criteria.Results Twenty-seven studies were included with 69816 samples.The pooled HBV infection rate in HIV positive population in China was 11.29%.The HBV co-infection rate was higher in the western China(10.73%)and southern China(14.18%),while lower in northern China(6.36%).The HBV infection rates were 11.22%,12.76%,9.58%,11.32%and 10.34%,respectively,in HIV-positive population infected through blood or blood products transfusion,intravenous drug use,homosexual contact,heterosexual contact and unknown transmission routes.Population infected with HIV caused by mother-to-child transmission had the lowest HBV infection rate(2.87%).The HBV infection rate in HIV positive males was 1.29 times higher than that in HIV positive females in southern China.Conclusions The HBV infection rate in HIV positive population is significantly higher than that in general population.More attention should be paid to the prevention and control of HBV co-infection in HIV positive population.

关 键 词：HIV感染者 HBV感染率 META分析 

分 类 号：R512.62[医药卫生—内科学] R512.91[医药卫生—临床医学]