中空介孔二氧化硅在生物医学领域中的应用研究进展  

The Research Progress in the Application of Hollow Mesoporous Silica in the Field of Biomedicine

作　　者：资鹏鹏 游清徽 徐贤柱[1] 谢振 王曼莹[1] 蔡险峰[1] ZI Pengpeng;YOU Qinghui;XU Xianzhu;XIE Zhen;WANG Manying;CAI Xianfeng(College of Life Science,Key Laboratory of the Conservation and Sustainable Utilization for Subtropical Plant Resources of Jiangxi Province,Jiangxi Normal University,Nanchang Jiangxi 330022,China)

机构地区：[1]江西师范大学生命科学学院,江西省亚热带植物资源保护与利用重点实验室,江西南昌330022

出　　处：《江西师范大学学报（自然科学版）》2021年第1期86-93,共8页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家“重大新药创制”科技重大专项(2018ZX09721002-008);江西省教育厅成果落地重点课题(GJJ10006)资助项目.

摘　　要：中空介孔二氧化硅具有中空腔结构、低密度、大比表面积、良好的生物相容性和稳定性以及表面易修饰等理化特性,在生物医学领域中受到广泛关注.该文主要概括了近年来功能化中空介孔二氧化硅在药物控释、靶向和生物成像中的应用研究进展,同时对目前中空介孔二氧化硅在临床应用中面临的问题进行了分析.Hollow mesoporous silica has a hollow cavity structure,low density,large specific surface area,good biocompatibility and stability,easy surface modification and other physical and chemical properties,and has attracted wide attention in the biomedical field.The research progress of functionalized hollow mesoporous silica in drug controlled release,targeting and bioimaging applications in recent years is mainly summarized,and the current problems of hollow mesoporous silica in clinical applications are analyzed.

关 键 词：中空介孔二氧化硅 药物控释 靶向 生物成像 

分 类 号：R944[医药卫生—药剂学]