多重氢键增强的带乙烯基二氨基三嗪水凝胶的记忆性能与药物的选择吸附  

Shape memory properties and selective adsorption of drugs of multiple hydrogenbondsreinforced hydrogels with vinyl diaminotriazine

作　　者：彭雪银 李学锋 李荣哲[1] 李婕 龙世军 黄以万 PENG Xueyin;LI Xuefeng;LI Rongzhe;LI Jie;LONG Shijun;HUANG Yiwan(School of Materials and Chemical Engineering,Hubei University of Technology,Wuhan 430068,China;Hubei Provincial Key Laboratory of Green Materials for Light Industry,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学材料与化学工程学院,武汉430068 [2]湖北工业大学绿色轻工材料湖北省重点实验室,武汉430068

出　　处：《复合材料学报》2021年第2期470-478,共9页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(51273059;51903079);武汉市科学技术局应用基础前沿项目(2019010701011397)。

摘　　要：制备了多重氢键增强的水凝胶聚(丙烯酰胺-co-2-乙烯基-4,6-二氨基-1,3,5-三嗪)/单宁酸(P(Am-coVDT)/TA)。通过对力学性能、微观形貌和红外光谱的测试和分析,发现TA通过氢键交联了水凝胶,使其结构更加致密,且水凝胶具有高的拉伸强度(2.34 MPa)和断裂伸长率(410%)。这是由于聚合物链上的二氨基三嗪(DAT)部分与TA的邻苯三酚/邻苯二酚基团之间形成氢键"软"区域;DAT部分与其自身形成氢键"硬"区域,通过"软""硬"区域的协同作用,使水凝胶获得了优异的力学性能。由于存在多重氢键,水凝胶还具有形状记忆的快速响应性。可以在短时间内通过改变温度快速成型和恢复形状,形变可重复多次。此外,水凝胶还具有物理吸附抗炎药物双氯芬酸钠(DS)的能力。此研究将在生物医学,组织工程和医学材料等领域中具有重要意义。The multiple H-bonds reinforced poly(acrylamide-co-2-vinyl-4,6-diamino-2-vinyl-1,3,5-triazine)/tannic acid(P(Am-co-VDT)/TA) hydrogels were prepared. Through testing and analysis of mechanical properties, micro-morphology and infrared spectrum, it’s found that TA cross-linked the hydrogel through hydrogen bonding,making its structure more dense, and the hydrogel has high tensile strength(2.34 MPa) and elongation at break(410%). This is due to the formation of hydrogen-bond "soft" regions between the diaminotriazine(DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups and a "hard" region of H-bonds forming by DAT moieties with itself. Such soft and hard dual-physically crosslinked networks dramatically enhance the mechanical properties of hydrogels in a synergistic manner. Due to the multiple hydrogen bonds, the hydrogel can rapidly response to shape memory within a few minutes. It can be quickly shaped and restored by changing the temperature,and the shape change can be maintained and repeated for many times. In addition, the hydrogels have capacity of physical adsorption of anti-inflammatory drug diclofenac sodium(DS) and other molecules with a specific spatially arranged chemical composition. This research will be of great significance in the fields of biomedicine, tissue engineering and medical materials.

关 键 词：形状记忆 二氨基三嗪 高强度水凝胶 多重氢键 药物吸附 

分 类 号：TQ427.26[化学工程] TQ460.4