可交联磷酰胆碱聚合物改性聚甲基戊烯中空纤维膜  

Cross-linkable phosphonylcholine polymer modified polymethylpentene hollow fiber membrane

作　　者：叶非华 易国斌[1] YE Feihua;YI Guobin(School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China;Guangdong Shunde Industrial Design Institute(Guangdong Shunde Innovative Design Institute),Foshan 528300,China)

机构地区：[1]广东工业大学轻工化工学院,广州510006 [2]广东顺德工业设计研究院(广东顺德创新设计研究院),佛山528300

出　　处：《复合材料学报》2021年第2期479-486,共8页Acta Materiae Compositae Sinica

基　　金：广东省高校创新强校重大科研项目(2017KZDXM026)。

摘　　要：通过自由基聚合反应制备了可交联磷酰胆碱聚合物(Poly(MPC-co-LMA-co-TSMA), PMLT)。将该聚合物溶液涂覆在聚甲基戊烯中空纤维膜(PMPHFM)表面,经交联处理后可形成稳定的PMLT聚合物涂层,得到改性复合材料PMLT/PMPHFM。溶胀度测试表明PMLT聚合物膜具有良好的亲水性能,且溶胀度随着2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)含量和温度的升高而增大。ATR-FTIR和XPS分析表明PMLT/PMPHFM表面的PMLT聚合物涂层含有磷酰胆碱基团。SEM和荧光测试结果显示PMLT/PMPHFM表面包覆有均匀的聚合物涂层,且该涂层能够抵抗乙醇溶液和十二烷基硫酸钠溶液的溶解。血小板黏附和全血接触测试表明,相比空白PMPHFM,PMLT聚合物涂层能够显著减少PMPHFM表面的血小板黏附,降低血液凝结风险。研究结果表明:可交联磷酰胆碱聚合物PMLT具有良好的亲水性能,能够均匀涂覆在PMPHFM的表面,得到具有良好血液相容性的复合材料PMLT/PMPHFM。Cross-linkable phosphorylcholine polymer(Poly(MPC-co-LMA-co-TSMA), PMLT) was prepared by free radical polymerization. Coating the copolymer solution on the surface of polymethylpentene hollow fiber membrane(PMPHFM) can form a stable polymer coating after the cross-linking treatment and obtain a modified composite material PMLT/PMPHFM. The swelling test shows that the PMLT copolymer has good hydrophilic properties, and the swelling degree increases with the increase of MPC content and temperature. ATR-FTIR and XPS analysis show that the polymer coating containing phosphorylcholine groups exist on the surface of PMLT/PMPHFM.SEM and fluorescence test results show that the surface of PMLT/PMPHFM is coated with a uniform polymer coating, and the coating could resist the dissolution of ethanol and SDS aqueous solution. Platelet adhesion and whole blood contact tests show that the coating could reduce platelet adhesion on the surface of PMPHFM, reduce the risk of blood clotting compared to bare PMPHFM. The results show that the PMLT copolymer has good hydrophilic property, and can be uniformly coated on the surface of PMPHFM to obtain a composite material PMLT/PMPHFM with good blood compatibility.

关 键 词：磷酰胆碱聚合物 表面改性 聚甲基戊烯中空纤维膜(PMPHFM) 涂层 血液相容性 

分 类 号：TB332[一般工业技术—材料科学与工程] TQ316.6[化学工程—高聚物工业]