5%阿莫罗芬搽剂治疗68例远端侧位甲下型甲真菌病的临床疗效观察  

Clinical observation of 5%amorolfine liniment in the treatment of 68 cases of distal lateral subungual onychomycosis

作　　者：胡馨 王延龙[1] 吕莎[1] 林怡彤 李福秋[1] HU Xin;WANG Yanlong;LV Sha;LIN Yitong;LI Fuqiu(Department of Dermatology and Venereology, The Second Hospital of Jilin University, Changchun 130041, China)

机构地区：[1]吉林大学第二医院皮肤性病科,长春130041

出　　处：《中国真菌学杂志》2021年第2期90-95,112,共7页Chinese Journal of Mycology

摘　　要：目的观察5%阿莫罗芬搽剂治疗远端侧位甲下型甲真菌病的疗效及安全性。方法招募具有远端侧位甲下型甲真菌病典型临床表现且真菌镜检阳性患者,应用5%阿莫罗芬搽剂治疗36周(每周1次)。计算临床有效率、真菌学清除率、治疗前后甲真菌病临床评分和甲真菌病严重程度指数及治疗前后生活质量评分,记录患者不良反应及满意度。收集病甲组织行真菌培养。结果共招募68例患者,总体临床有效率为66.1%;真菌学清除率为82.4%,第2~5趾甲受累患者临床有效及真菌学清除率较高,治疗过程中除轻微脱屑、灼热及红斑外,所有患者均耐受治疗。76.47%患者对治疗效果感到满意。治疗前后患者生活质量改善显著。结论5%阿莫罗芬搽剂是治疗远端侧位甲下型甲真菌病的一种安全有效的方法,可用于抗拒或不适合系统用药的患者。Objective To observe the efficacy and safety of 5%amorolfine liniment in the treatment of distal lateral subungual onychomycosis.Methods Cases with typical clinical manifestations of distal lateral subungual onychomycosis and positive fungal microscopy were topically applied by 5%amorolfine liniment for 36-week(once a week).Calculating the clinical effective rate,mycological clearance rate,the scoring clinical index of onychomycosis,the onychomycosis severity index and the dermatology life quality index before and after treatment.Recording the patient's adverse reactions and satisfaction.Collecting diseased nail tissue for fungal culture.Results Sixty-eight patients were recruited,and the clinical effective rate was 66.1%;the mycological clearance was 82.4%.The clinically effective and the mycological clearance of 2nd-5th toenail affected patients were higher.Except for slight pain,burning and erythema,all patients were tolerated.76.47%of the patients were satisfied with the treatment effect.The life quality improved significantly before and after.Conclusion 5%amorolfine liniment is a safe and effective approach for distal lateral subungual onychomycosis,and can be used for patients who resist or are not suitable for systemic medication.

关 键 词：甲真菌病 阿莫罗芬 局部治疗 

分 类 号：R756.4[医药卫生—皮肤病学与性病学]