播散性马尔尼菲篮状菌病1例  

A case of disseminated Talaromyces marneffei

作　　者：吴荣群 徐文英[1] 李丽丽[1] 陈杏春[2] 韦海明[3] 谢治[1] WU Rongqun;XU Wenying;LI Lili;CHEN Xingchun;WEI Haiming;XIE Zhi(Guangxi Zhuang Autonomous Region People′s Hospital, Department of Dermatology,Nanning 530000, China;Guangxi Zhuang Autonomous Region People′s Hospital, Department of Laboratory Medicine,Nanning 530000, China;Guangxi Zhuang Autonomous Region People′s Hospital,Department of Pathology,Nanning 530000, China)

机构地区：[1]广西壮族自治区人民医院皮肤性病科,南宁530000 [2]广西壮族自治区人民医院检验科,南宁530000 [3]广西壮族自治区人民医院病理科,南宁530000

出　　处：《中国真菌学杂志》2021年第2期128-130,140,共4页Chinese Journal of Mycology

摘　　要：患者,男,32岁,反复淋巴结肿大、发热伴皮疹2年,广谱抗生素、抗结核治疗无效,肺部CT提示两肺内多发结节,血γ干扰素抗体阳性,皮肤活检组织、淋巴结组织、肺穿刺活检组织均培养出马尔尼菲篮状菌,予两性霉素B脂质体联合伏立康唑治疗效果佳。A 32-year-old man was admitted because of recurrent episodes of lymphadenectasis,fever and skin rashes for two years.Broad-spectrum antibiotics and anti-tuberculosis therapy were ineffective.Lung CT showed multiple nodules in both lungs and the serum was positive for anti-IFN-γ.Disseminated Talaromyces marneffei was diagnosed by skin biopsy,lymph node biopsy,lung biopsy.Amphotericin B liposome combined with voriconazole had a good therapeutic effect.

关 键 词：马尔尼菲篮状菌病 非艾滋病患者 γ干扰素抗体 

分 类 号：R519.8[医药卫生—内科学]