Pax3和Pax7在胚胎发育早期及神经嵴形成中的作用  

The role of Pax3 and Pax7 in early embryonic development and neural crest formation

作　　者：李云晓 杨慈清 林俊堂 LI Yunxiao;YANG Ciqing;LIN Juntang(School of Life Sciences and Technology,Xinxiang Medical University,Xinxiang 453003,China;Stem Cells and Biotherapy Engineering Research Center of Henan,Xinxiang 453003,China;Henan Key Laboratory of Medical Tissue Regeneration,Xinxiang 453003,China)

机构地区：[1]新乡医学院生命科学技术学院,新乡453003 [2]河南省干细胞与治疗工程研究中心,新乡453003 [3]河南省医用组织再生重点实验室,新乡453003

出　　处：《生物学杂志》2021年第2期100-104,共5页Journal of Biology

基　　金：国家自然基金项目(编号:81771226);河南省高校创新团队(编号:19IRTSTHN003);新乡医学院研究生科研创新支持计划(编号:YJSCX201906Z)。

摘　　要：配对盒(Paired box,Pax)基因是一个高度保守的转录因子基因家族,在胚胎模式化和器官发生中起关键作用。Pax3和Pax7具有相似的蛋白质结构和生物学功能,同属于Pax基因第三亚家族,在中枢神经系统、神经嵴和骨骼肌的发育过程中表达。研究表明,Pax3和Pax7通过整合来自Wnts、骨形成蛋白(BMPs)和成纤维细胞生长因子(FGFs)的信号联合调控神经嵴的发生发育。对不同的脊椎动物发育模型的研究共同阐明了神经嵴基因调控网络(NC-GRN)中涉及Pax3和Pax7基因的分子机制。针对Pax3和Pax7基因的生物学特性及其在胚胎发育早期的功能,特别是二者对神经嵴发生发育的调控机制的最新研究进展作简要概述,为Pax3和Pax7相关研究提供理论基础,也为神经嵴异常相关疾病提供新的研究方向。Paired boxgene is a highly conserved transcription factor gene family,which plays a key role in embryonic modeling and organogenesis.Pax3 and Pax7,belonging to the third subfamily of Pax gene,have similar protein structure and biological function,and are expressed during the development of central nervous system,neural crest and skeletal muscle.Studies have shown that Pax3 and Pax7 regulate the genesis and development of neural crest by integrating signals from Wnts,bone morphogenetic protein(BMPs)and fibroblast growth factor(FGFs).Studies on different vertebrate developmental models have jointly clarified the molecular mechanisms of Pax3 and Pax7 genes involved in the neural crest gene regulatory network(NC-GRN).The biological characteristics and functions of Pax3 and Pax7 genes in the early stage of embryonic development,especially the latest research progress on the regulation mechanism of neural crest genesis and development,which would provide a theoretical basis for the study of Pax3 and Pax7,and a new research direction for diseases related to abnormal neural crest.

关 键 词：PAX3 Pax7 神经发育 神经嵴 NC-GRN 

分 类 号：Q42[生物学—神经生物学] Q132.4[生物学—生理学]