Gremlin促血管生成作用的研究进展  

Research progress on the role of Gremlin in promoting angiogenesis

作　　者：谢宇欣(综述) 石国庆(审校) XIE Yu-xin;SHI Guo-qing(The Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)

机构地区：[1]遵义医科大学附属医院,贵州遵义563000

出　　处：《海南医学》2021年第7期899-903,共5页Hainan Medical Journal

基　　金：贵州省遵义市联合基金项目[编号:遵市科合社字(2018)99]。

摘　　要：Gremlin是半胱氨酸结超家族的成员,在发育过程中通过抑制骨形态形成蛋白(BMP)途径发挥作用,属于BMP拮抗剂。然而,Gremlin还有一些与BMP信号通路无关的功能。近年来的研究发现,Gremlin还是一种新型的VEGFR2激动剂,与血管生成相关性疾病有关。因此,Gremlin作为一种新型促血管生成因子,Gremlin-VEGFR2是血管生成的非经典途径信号通路。本文就Gremlin通过VEGFR2途径促血管生成作用在相关疾病中的研究进展做一综述。Gremlin,a member of the cysteine knot superfamily,is a bone morphogenetic protein(BMP)antagonist that plays a role in the development process by inhibiting BMP pathway.However,Gremlin also has some functions that are independent of BMP signaling pathway.In recent years,Gremlin has been found to be a novel VEGFR2 agonist associated with angiogenesis-related diseases.Therefore,Gremlin is a novel pro-angiogenic factor,and Gremlin-VEGFR2 is a non-classical signaling pathway for angiogenesis.This article reviews Gremlin's role in promoting angiogenesis through VEGFR2 pathway in related diseases.

关 键 词：GREMLIN VEGFR2 新型VEGFR2激动剂 非经典途径信号通路 血管生成 

分 类 号：R543[医药卫生—心血管疾病]