肌球蛋白轻链激酶介导的肌球蛋白调节轻链磷酸化研究  

Study on Myosin Light Chain Phosphorylation Mediated by Myosin Light Chain Kinase

作　　者：高文 李科 李雪萍[1] 李亚[2] 宋梅 GAO Wen;LI Ke;LI Xue-ping;LI Ya;SONG Mei(The Clinical Medicine College of Xi'an Medical University,Xi'an 710021,Shaanxi,China;The First Affiliated Hospital of Xi'an Medical University,Xi'an 710003,Shaanxi,China)

机构地区：[1]西安医学院临床医学院,陕西西安710021 [2]西安医学院第一附属医院,陕西西安710003

出　　处：《医学信息》2021年第8期28-30,35,共4页Journal of Medical Information

基　　金：国家自然科学基金项目(编号:81801863)。

摘　　要：肌球蛋白轻链激酶(MLCK)是一种Ca2+/CaM(钙调素)依赖性蛋白激酶,通过介导肌球蛋白调节轻链(RLC)磷酸化促进肌肉的收缩。近年来研究发现RLC磷酸化在细胞病理生理功能中起着重要作用,本文就MLCK介导的RLC磷酸化最新研究进展作一综述。Myosin light chain kinase(MLCK)is a Ca2+/CaM(calmodulin)-dependent protein kinase that promotes muscle contraction by mediating myosin-regulated light chain(RLC)phosphorylation.In recent years,studies have found that RLC phosphorylation plays an important role in cell pathophysiological functions.This article reviews the latest research progress of MLCK-mediated RLC phosphorylation.

关 键 词：肌球蛋白轻链激酶 肌球蛋白调节轻链 肌肉收缩 

分 类 号：Q512.2[生物学—生物化学]