以参芪为主扶正方治疗恶性肿瘤患者疗效的Meta分析  

Therapeutic Effect of Fuzheng Formula Mainly Containing Shenqi on Malignant Tumor:A Meta-analysis

作　　者：李恒震 王帅[2] 蔡新生 高建喆 LI Hengzhen;WANG Shuai;CAI Xinsheng;GAO Jianzhe(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Weifang Traditional Chinese Hospital of Shandong Province,Weifang 261000,China)

机构地区：[1]山东中医药大学,济南250355 [2]山东省潍坊市中医院,潍坊261000

出　　处：《世界中医药》2021年第5期795-801,共7页World Chinese Medicine

基　　金：山东省卫生厅基金山东省医药科技发展计划项目(2018WS068)。

摘　　要：目的:评估以参芪为主的扶正方及中成药配合化疗药物治疗恶性肿瘤的疗效。方法:通过计算机检索国家知识基础设施数据库(简称中国知网,China National Knowledge Infrastructure,CNKI)、中文科技期刊数据库(简称维普资讯,Chinese Citation Database,CCD)、中国学术期刊数据库(简称万方数据库,China Science Periodical Database,CSPD)等国内数据库以及PubMed、OVID、EmBase等国外数据库,查找有关以参芪为主的扶正方治疗恶性肿瘤的随机对照试验的中英文文献,检索时间为2015年10月到2020年3月。使用RevMan5.3软件对挑选出的文献提取相关数据,针对扶正方的疗效进行数据分析,比较观察组与对照组差异。结果:纳入18篇文献,共计1724例患者,结果显示观察组疗效优于对照组(RR=1.46,95%CI:1.35~1.59,P<0.00001)。结论:以参芪为主的扶正方配合化疗治疗恶性肿瘤能够抑制肿瘤生长、增强免疫功能、提高生命质量、减少不良反应发生率。Objective:To evaluate the efficacy of ShenQi Fuzheng Formula and Chinese patent medicine combined with chemotherapy drugs in the treatment of malignance cancer.Methods:Through computer search of domestic databases such as CNKI,VIP database,Wanfang database and foreign databases such as PubMed,OVID,EmBase,etc.,we searched for Chinese and English literature on randomized controlled trials of Shenqi-based Fuzheng Formula in the treatment of malignant tumors.The retrieval time was nearly 5 years.RevMan5.3 software was used to extract relevant data from selected documents,to analyze the efficacy of Fuzheng Formula,and to compare the differences between the test group and the control group.Results:A total of 18 papers were included,totaling 1724 patients.The results showed that the test group was superior to the control group in the whole course of treatment of malignant tumors[RR=1.46,95%CI(1.35~1.59),P<0.00001].Conclusion:ShenQi Fuzheng Formula combined with chemotherapy in the treatment of malignant tumors can inhibit tumor growth,enhance immune function,improve quality of life and reduce the incidence of adverse reactions.The application of this method can effectively treat malignant tumors.

关 键 词：扶正 黄芪 人参 恶性肿瘤 免疫功能 生命质量 中医 化疗 META分析 

分 类 号：R273[医药卫生—中西医结合] R282[医药卫生—中医肿瘤科]