免疫透射比浊法常见干扰因素的识别与应对策略  

Detection and prevention of common interference in turbidimetric immunoassay

作　　者：贾珂珂[1] 孙文苑 聂睿 崔丽艳[1] JIA Keke;SUN Wenyuan;NIE Rui;CUI Liyan(Department of Clinical Laboratory,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院检验科,北京100191

出　　处：《检验医学》2021年第4期362-368,共7页Laboratory Medicine

摘　　要：免疫透射比浊法检测结果的准确性常受到一些干扰因素的影响,如样本性状、内源性干扰、钩状效应和携带污染等,这些干扰因素可使检测结果假性升高或降低,影响临床诊断和治疗监测等。文章对免疫透射比浊法常见的干扰因素及机制进行综述,以帮助检验人员识别和确认可能存在的干扰,及时纠正检测结果,尽可能减少不良后果的发生。The accuracy of turbidimetric immunoassay is affected by a few interference factors,such as sample appearance,endogenous interference,hook effect and carry-over contamination.These interference factors may cause the results increasing or decreasing falsely and further affect clinical diagnosis and treatment monitoring.The laboratory staff should be familiar with common interference factors and mechanisms,communicate with doctors in time and identify,confirm and prevent possible interference,in order to reduce the occurrence of adverse events.

关 键 词：免疫透射比浊法 样本性状 内源性干扰 钩状效应 携带污染 干扰 

分 类 号：R446.1[医药卫生—诊断学]