右美托咪定术前给药对老年四肢骨折全麻患者术后恢复期的影响及使用安全性探究  

Effect of preoperative administration of dexmedetomidine on postoperative recovery of elderly patients with general extremity fractures and safety of use

作　　者：艾广兴[1] AI Guangxing(Department of Anesthesiology,Fuxin Central Hospital,Liaoning Province,Fuxin,Liaoning,123000,China)

机构地区：[1]辽宁省阜新市中心医院麻醉科,辽宁阜新123000

出　　处：《当代医学》2021年第12期35-37,共3页Contemporary Medicine

摘　　要：目的研究右美托咪定术前给药对老年四肢骨折全麻患者术后恢复期的影响及使用安全性。方法选取2018年10月至2019年10月本院收治的老年四肢骨折患者89例,随机分为实验组(n=45)和常规组(n=44)。常规组给予术前泵注0.9%氯化钠溶液,实验组术前给予右泵注美托咪定。比较两组患者手术一般情况、全麻恢复相关指标、认知障碍、心率、血压及血氧饱和度情况。结果两组手术时间、出血量、麻醉时间、输液量比较差异均无统计学意义,术后实验组定向力恢复时间、睁眼时间、自主呼吸时间Aldrete评分>9分时间显著低于常规组(P<0.05),实验组苏醒期Riker镇静躁动评分显著高于常规组(P<0.05)。手术前,两组MMSE比较差异无统计学意义;手术后1 d,常规组显著降低(P<0.05),差异有统计学意义(P<0.05);手术后3 d,实验组MMSE显著高于常规组(P<0.05)。手术前,两组收缩压、心率、血氧饱和度比较差异无统计学意义;手术后,两组收缩压与血样饱和度比较差异无统计学意义,实验组心率显著低于常规组(P<0.05)。结论对老年四肢骨折患者实施术前右美托咪定给药,能有效降低患者向力恢复时间、睁眼时间、自主呼吸时间Aldrete评分>9分时间、心率,同时改善患者精神状态,安全性较高,值得临床推广。Objective To study the effect of preoperative administration of dexmedetomidine on the recovery period of patients with general anesthesia of extremities and the safety of use.Methods 89 elderly patients with extremity fractures admitted to our hospital from October 2018 to October 2019 were randomly divided into experimental group(n=45)and conventional group(n=44).The conventional group was given a saline injection before surgery,and the experimental group was given a right pumping metopidine before surgery.The general conditions of the two groups of patients were compared,and the indicators of general anesthesia recovery,cognitive impairment,heart rate,blood pressure and oxygen saturation were compared between the two groups.Results There was no significant difference in operation time,blood loss,anesthesia time and infusion volume between the two groups.The postoperative recovery time,blink time and spontaneous breathing time Aldrete score of the experimental group were significantly lower than the conventional time.The Riker sedation and agitation scores in the experimental group were significantly higher than those in the conventional group(P<0.05).There was no significant difference of MMSE between the two groups before operation,and the MMSE conventional group was significantly decreased 1 day after surgery,there was significant difference between the two groups(P<0.05),the MMSE in the experimental group was significantly higher than that in the conventional group 3 days after surgery(P<0.05).There was no significant difference in the systolic blood pressure,heart rate and blood oxygen between the two groups before the operation.There was no significant difference in systolic blood pressure and blood saturation between the two groups after operation,the heart rate of the experimental group was significantly lower than that of the conventional group(P<0.05).Conclusion In summary as mentioned,preoperative dexmedetomidine administration in elderly patients with limb fractures can effectively reduce the patien

关 键 词：右美托咪定 术前给药 老年四肢骨折 全麻 恢复期 安全性 

分 类 号：R614[医药卫生—麻醉学]