长链非编码核糖核酸与冠心病的研究进展——从发病机制到诊断与治疗  

Research progress in long noncoding RNAs in coronary heart disease: pathogenesis, diagnosis and therapy

作　　者：杨环莞 刘昱圻[1] 陈韵岱[1] YANG Huan-Wan;LIU Yu-Qi;CHEN Yun-Dai(Department of Cardiology,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心心血管内科,北京100853

出　　处：《中华老年多器官疾病杂志》2021年第4期313-316,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：中国中青年临床研究基金-V.G基金(2017-CCA-VG-04);北京力生心血管健康基金会领航基金重点项目。

摘　　要：心血管疾病患病率高,死亡率亦居高不下,是目前世界范围内重大的公共卫生问题之一,其中冠心病心肌梗死仍是导致死亡的主要原因之一。随着微阵列及高通量测序技术的飞速发展,长链非编码核糖核酸(lncRNA)在心血管疾病发生发展中的作用被逐渐揭示。lncRNA通过表观遗传等作用形式在转录及转录后水平对基因表达进行调控。已有大量研究表明,lncRNA在动脉粥样硬化、急性心肌梗死等疾病中发挥重要调节作用。本文将对lncRNA的生物学作用模式,及其在冠心病发病、诊断及治疗等领域的研究进展做一综述。Cardiovascular disease remains one of the major public health problems worldwide with high morbidity and mortality,and myocardial infarction remains the leading cause of death.The rapid development of microarray technology and high-throughput sequencing technology helps to gradually reveal the role of long non-coding RNA(lncRNA)in the occurrence and development of cardiovascular disease.LncRNA regulates gene expression at transcriptional and post-transcriptional levels through epigenetic action.A large number of studies have shown that lncRNA plays an important role in the regulation of atherosclerosis,acute myocardial infarction,and other cardiovascular diseases.This article reviews the biological mode of lncRNA and research progress in its role in the pathogenesis,diagnosis and treatment of coronary heart disease.

关 键 词：长链非编码核糖核酸 冠心病 发病机制 诊断 治疗 

分 类 号：R541.4[医药卫生—心血管疾病]