蛋白激酶CK2在神经退行性疾病病理生理机制中的作用及应用进展  

Role and Application Progress of Protein Kinase CK2 in the Pathophysiological Mechanisms of Neurodegenerative Diseases

作　　者：崔孟颖 冯其贞 武菲[1] CUI Meng-Ying;FENG Qi-Zhen;WU Fei(Institute of Neurobiology,Jining Medical University,Jining 272067,China)

机构地区：[1]神经生物学研究所,济宁医学院,济宁272067

出　　处：《生理科学进展》2021年第2期88-93,共6页Progress in Physiological Sciences

基　　金：国家自然科学基金(81870948);山东省自然科学基金(ZR2019PC007);山东省医药卫生科技发展计划项目(2016WS0162);济宁医学院青年教师科研扶持基金(JYFC2018KJ022);济宁医学院大学生创新训练计划项目(cx2018031)资助课题。

摘　　要：蛋白激酶CK2(casein kinase 2,CK2)是一种高度保守的丝/苏氨酸蛋白激酶,广泛分布于真核细胞的胞质和胞核中。CK2可通过对其底物的磷酸化作用调制底物的生物学活性,从而参与细胞内多条重要的信号转导通路。越来越多的研究发现,在多种神经退行性疾病中CK2表达及活性异常,是其病理生理机制的重要一环,提示CK2有重要的研究意义,可能是某些神经退行性疾病潜在的治疗靶点。本文将对CK2在多种神经退行性疾病中病理生理作用以及CK2抑制剂、激动剂的最新研究进展作一综述。Protein kinase CK2 is a highly conserved serine/threonine protein kinase,which is widely distributed in the cytoplasm and nucleus of eukaryotic cells.CK2 could modulate the biological activity of its substrates via phosphorylation,thus participating in many important cellular signal transduction pathways.More and more evidences have proved the abnormal expression and activity of CK2 in neurodegenerative diseases,and have demonstrated that CK2 may be one of the pathophysiological mechanisms,suggesting that CK2 is of great value to study and may be an effective new target for some neurodegenerative diseases.In the present review,we focused on the recent progress of CK2 in various neurodegenerative diseases and inhibitors and activators of CK2.

关 键 词：CK2 神经退行性疾病 CK2抑制剂 

分 类 号：R338[医药卫生—人体生理学]